grant
Synergistic Effect of Nicotine and Antiretrovirals on Placental Development
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years old72-kDa Gelatinase72-kDa Type IV Collagenase72kD type IV CollagenaseAdverse effectsAffectAlcohol Chemical ClassAlcoholsAnti-Retroviral AgentsAssayAttenuatedBioassayBiological AssayBiological MarkersBirthBloodBlood PlasmaBlood Reticuloendothelial SystemBlood flowBody TissuesCannabinoidsCell BodyCell Culture TechniquesCellsCells Placenta-TissueChildChild YouthChildren (0-21)CocaineCrystal MethCrystal methamphetamineCytotoxic cellDWI (diffusion weighted imaging)DWI-MRIDataDeoxyephedrineDesoxyephedrineDevelopmentDiameterDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDoseDrug ExposureDrug KineticsDrugsEncapsulatedExposure toFetal GrowthFetal Growth RestrictionFetal Growth RetardationFormulationGelatinase AGelatinase NeutrophilGeneralized GrowthGestationGrowthHIV-1HIV-IHIV1HumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1HypoxiaHypoxicIUGRImmuneImmunesImmunoblottingImpairmentIn vivo analysisInjectableIntegraseIntrauterine Growth RetardationInvadedK lymphocyteKnowledgeLinkLow Birth Weight InfantMMP-2MMPsMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMaternal HealthMatrix Metalloproteinase-2Matrix MetalloproteinasesMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethamphetamineMethylamphetamineMiceMice MammalsModern ManMorbidityMorbidity - disease rateMorphogenesisMorphologyMothersMurineMusN-MethylamphetamineNK CellsNMR ImagingNMR TomographyNatural Killer CellsNeural DevelopmentNicotineNormal PlacentomaNuclear Magnetic Resonance ImagingOpiatesOpioidOral AdministrationOral Drug AdministrationOutcomeOxygen DeficiencyParturitionPathologyPeripheralPharmaceutical PreparationsPharmacokineticsPlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacental ToxicityPlacentationPlacentomePlasmaPlasma SerumPoloxamersPregnancyPregnancy ComplicationsPregnancy OutcomePregnant WomenPremature BirthPrematurely deliveringPreterm BirthPropertyProteinsProteomicsRegimenResearchReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRisk ReductionRodent ModelSafetySamplingSmokingSpiral ArterySpiral Artery of the EndometriumSyncytiotrophoblastSystemTestingTherapeuticTissue GrowthTissuesTobacco ConsumptionTobacco useToxic effectToxicitiesTransmissionUterusVillousWestern BlottingWestern ImmunoblottingWomanWorkZeugmatographyadverse event riskanti-retroviralantiretroviral therapyantiretroviral treatmentattenuateattenuatesbio-markersbiologic markerbiomarkercell culturecell culturescell typeclinical relevanceclinically relevantco-morbidco-morbiditycomorbiditycomparing females and malescomparing women and mencomplications during pregnancycostcytotrophoblastdMRIdevelopmentaldiffusion tensor imagingdosagedrug/agentexpectant motherexpectant womenexpectationexpecting motherexpecting womenexposure to nicotinefemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfetalimpaired fetal growthimprovedin uteroin vivo evaluationin vivo testingindividuals who are pregnantinhibitorintra-uterine growthintra-uterine growth restrictionintra-uterine growth retardationintraoral drug deliveryintrauterine growthintrauterine growth restrictionkidslow birth weightlow birthweightmethmigrationmorphogenetic processmortalitynano formulationnanoformulationneonatal morbidityneurodevelopmentnewborn morbiditynicotine consumptionnicotine exposurenicotine useontogenypeople who are pregnantplacenta morphologyplacental morphologypregnancy-related complicationspregnantpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliveryprenatal growth disorderpreterm deliveryprotein blottingrecruitreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk-reducingsubstance usesubstance usingsurfactantthose who are pregnanttobacco product usetransmission processtrophoblasttrophoblast progenitortrophoblast progenitor celltrophoblast stem cellwombwomen compared to menwomen compared with menwomen versus menwomen vs. menwomen who are pregnantyoungster
Description preview
Project Summary
Background: The number of women living with human immunodeficiency virus type 1 (HIV-1) getting pregnant
while on antiretroviral therapy is steadily rising. This is due to the growing availability of antiretroviral drugs
(ARVs) at affordable access worldwide. Each year, more than a million women LWH have given birth while on
ART.…
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