grant
Synaptotagmin C2B Domain as a Ca2+ Sensing Module
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Mar 2002Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Acidic Amino AcidsAction PotentialsAcuteAddressAmmon HornArtifactsAssayAutomobile DrivingBackBindingBinding SitesBioassayBiological AssayBrainBrain Nervous SystemBrain regionC 2aC2 DomainC2aC2bCalorimetryCombining SiteCommunicationConfusionConfusional StateCornu AmmonisCorpus StriatumCorpus striatum structureCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDataDense Core VesicleDockingDopamineDorsalDorsumDoseElectron CryomicroscopyElectron MicroscopyEncephalonEndocrine Gland SecretionEuler-Gaddum Substance PExocytosisFreezingGene FamilyGenetic ChangeGenetic defectGenetic mutationGoalsHeadHippocampusHormonesHydroxytyramineImageImpairmentIndividualIonsIsoformsLigandsMeasurementMediatingMental ConfusionModelingMolecular InteractionMorphologic artifactsMsecMutationNerveNerve CellsNerve Transmitter SubstancesNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurologic functionNeurological functionNeuromodulatorNeuronsNeurotransmittersPathologyPatientsPhysiologic pulsePlayPreparationProcessPropertyProtein IsoformsPulseReactive SiteReportingResearchResistanceRoleSchizophreniaSchizophrenic DisordersSideSliceStriate BodyStriatumStructureSubstance PSynaptic VesiclesSynaptic plasticityTestingTimeTitrationsTransmissionWorkaddictionaddictive disordercell typecomplement 2acomplement 2bcomplement C2acomplement C2a fragmentcomplement C2bcomplement C2b fragmentcryo-EMcryoEMcryogenic electron microscopydementia praecoxdrivingexperimentexperimental researchexperimental studyexperimentsgain of functiongenome mutationhippocampalimaginginsightinstrumentmembermillisecondmutantnervous system functionneurokinin 1neuronalneurotransmitter releasenoveloverexpressoverexpressionp65 proteinpharmacologicpreparationspresynapticreconstitutereconstitutionresistantresponseschizophrenicsensorsocial rolestriatalstriosomesynapse functionsynaptic depressionsynaptic functionsynaptic vesicle protein p65synaptotagminsynaptotagmin 1synaptotagmin Itomographytransmission processvesicle releasevesicular release
Description preview
Project Summary/Abstract
In this competitive renewal, we continue our studies of synaptotagmin (syt) isoforms that regulate the release
of neurotransmitters and hormones. The founding member of this gene family, syt1, was discovered in 1981
and has been shown to function as the major Ca2+ sensor for synchronous synaptic vesicle (SV) exocytosis in…
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