grant
Synaptic Function within Mature Central Pain Networks after Neonatal Injury
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 21 Sept 2013Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years old3-D3-Dimensional3DAdmissionAdmission activityAdultAdult HumanAstrocytesAstrocytusAstrogliaBehavioral AssayBody TissuesBrainBrain Nervous SystemCalciumCaringCell Communication and SignalingCell SignalingChildChild YouthChildren (0-21)Chiro-InositolConfocal MicroscopyDataEarly TraumaEarly-life traumaElectrophysiologyElectrophysiology (science)EncephalonEquilibriumFoundationsGeneticImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInfantInflammatoryInjuryInositolIntervention StrategiesIntracellular Communication and SignalingInvestigationKnowledgeLifeLinkLong-Term EffectsMediatingMedicalMedulla SpinalisMesoinositolMiceMice MammalsModelingMolecularMorphologyMurineMusNeonatalNeonatal Intensive Care UnitsNerve CellsNerve UnitNeural CellNeural TransmissionNeurocyteNeuroimmuneNeuronsNeurophysiology / ElectrophysiologyNewborn Intensive Care UnitsNociceptionOtomyOutcomeOutputPainPainfulPathogenesisPathologicPathway interactionsPeripheralPhenotypePhosphatesPopulationProcessProductionPublic HealthRNA SeqRNA sequencingRNAseqReceptor ProteinResearchRodentRodentiaRodents MammalsRoleSensorySeveritiesShapesSignal TransductionSignal Transduction SystemsSignalingSpinalSpinal CordSurgical InjuriesSurgical incisionsSynapsesSynapticSynaptic TransmissionTSP-1TSP1TestingThrombospondin 1TissuesTransmissionWorkadulthoodage associatedage correlatedage dependentage linkedage relatedage specificastrocytic gliabalancebalance functionbiological signal transductioncell typecentral painchronic painconditional knock-outconditional knockoutconfocal imagingcortical paincytokinedesigndesigningdorsal hornelectrophysiologicalexperienceimagingin vivoincisioninjuriesinjury to tissueinnovateinnovationinnovativeinorganic phosphateinsightkidslater in lifelater lifemouse geneticsmultidisciplinaryneonatal ICUneonatal injuryneonatal surgeryneural circuitneural circuitryneural inflammationneurocircuitryneuroinflammationneuroinflammatoryneuronalneuronal excitabilitynociceptivenovelpain perceptionpain sensitivitypain signalpatch clamppathwaypost-natal periodpostnatalpostnatal periodpre-clinicalpre-clinical studypreclinicalpreclinical studyreceptorsocial rolesynapsesynapse formationsynapse functionsynaptic circuitsynaptic circuitrysynaptic functionsynaptic pruningsynaptogenesisthree dimensionaltissue injurytranscriptome sequencingtranscriptomic sequencingtransmission processyoungster
Description preview
Project Summary/Abstract
Infants admitted to a neonatal intensive care unit (NICU) regularly experience tissue damage as part of
their essential medical care. Preclinical studies have shown that neonatal injury causes a prolonged
reorganization of synaptic circuits in the mouse spinal superficial dorsal horn (SDH), enhances neuroimmune
signaling…
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