grant
SYNAPTIC COMPUTATIONS IN CENTRAL VESTIBULAR NEURONS
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2017Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Anatomic SitesAnatomic structuresAnatomyAnimalsAutomobile DrivingBrachydanio rerioBrain StemBrainstemCategoriesCatsCats MammalsCell BodyCell Communication and SignalingCell SignalingCellsCerebellumCyclicityDanio rerioDataData SetDomestic CatsElectron MicroscopyElectronsEquilibriumExhibitsEye MovementsFeedbackFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusGenetic IdentityGoalsHeadHead MovementsImageImmobilizationInferiorInternal EarIntracellular Communication and SignalingInvestigatorsJobsLabelLabyrinthLamprey EelsLampreysLifeLocomotionMapsMeasuresMedulla SpinalisMotorMovementNatureNegative Beta ParticleNegatronsNerve CellsNerve UnitNeural CellNeurocyteNeuronsOccupationsOlivesOlives - dietaryPalsyParalysedPathway interactionsPeriodicityPetromyzontidaePhysiologicPhysiologicalPlegiaPopulationPosturePreparationPrimatesPrimates MammalsProfessional PositionsReflexReflex actionResearch PersonnelResearchersResolutionRhythmicitySensorySignal TransductionSignal Transduction SystemsSignalingSourceSpinalSpinal CordSynapsesSynapticTadpolesTestingTrainingTransgenic OrganismsVertebrate AnimalsVertebratesVestibularWalkingWhole-Cell RecordingsWorkZebra DanioZebra FishZebrafishbalancebalance functionbiological signal transductionbody movementcandidate identificationcatsconnectome dataconnectomic datadrivingexperimentexperimental researchexperimental studyexperimentsfootgazeimagingin vivoinner earinnovateinnovationinnovativelimb movementmicrographymotor controlneuronalocular motorocularmotoroculomotoroptogeneticsorthopedic freezingparalysisparalyticpatch clamppathwaypreparationspresynapticreconstructionresolutionssensory inputsynapsetransgenicvertebratavestibular systemvoltage clamp
Description preview
Project summary
Brainstem vestibulospinal neurons receive information about head movement from vestibular afferents, but for
unexplained reasons, during locomotion they also receive a copy of motor commands, in the form of a rhythmic
oscillation aligned with the locomotor cycle. It is unknown whether the job of this locomotor copy, known as a…
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