grant
Suppression of elevated intracellular Ca2+ as an early intervention to prevent vision loss
Organization VA GREATER LOS ANGELES HEALTHCARE SYSTEMLocation LOS ANGELES, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY2025ADAR2ADARB1 proteinAMPA ReceptorsAcuteAddressAnterior Ischemic Optic NeuropathyApoplexyApoptosisApoptosis PathwayAreaAtrophicAtrophyBehaviorBiologic ModelsBiological ModelsBlindnessBrain Vascular AccidentCalciumCell BodyCell ComponentsCell DeathCell FunctionCell PhysiologyCell ProcessCell ProtectionCell StructureCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StructuresCellular injuryCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicClinicalCranial Nerve IICranial Nerve II InjuriesCraniocerebral InjuriesCraniocerebral TraumaCytoprotectionDNA TherapyDRADA2b proteinDendritesDevelopmentDiminished VisionEarly InterventionEnzyme GeneEnzymesEventExcitatory SynapseEye InjuriesEye diseasesFoundationsGene FamilyGene Transfer ClinicalGenetic InterventionGenetic SuppressionGlaucomaGlutamate ReceptorGoalsHead InjuriesHead TraumaHealthHourInjuryInterventionIntraocular PressureInvestigationLightLight CellLow VisionMediatingModel SystemModelingMolecularMorphologyNerve Cell SurvivalNerve CrushNerve DegenerationNerve FibersNeuron DegenerationNeuronal InjuryOcular HypertensionOcular InjuryOcular TensionOptic NerveOptic Nerve InjuriesOptic Nerve TraumaPartial SightPathologicPermeabilityPhotoradiationPhysiologicPhysiologic Intraocular PressurePhysiologicalPlayProgrammed Cell DeathPropertyQOLQuality of lifeRNA EditingRNA, Messenger, EditingReceptor GeneReceptor ProteinReceptor Up-RegulationReduced VisionReportingRetinaRetinal Ganglion CellsRoleScotomaSecond Cranial NerveSecond Cranial Nerve InjuriesSecond Cranial Nerve TraumaSightSourceStrokeStructureSubcellular ProcessSubnormal VisionSynapsesSynapticSynaptic ReceptorsTestingTraumaTraumatic Optic NeuropathyVeteransVisionVisual Field DisorderVisual field scotomaVisual impairmentantagonismantagonistaxonal degenerationbrain attackcell damagecell injurycell typecellular damagecerebral vascular accidentcerebrovascular accidentcytoprotectivedamage to cellsdegenerative axondevelopmentalextracellulareye disordereye traumagene repair therapygene therapygene-based therapygenetic approachgenetic strategygenetic therapygenomic therapyglaucomatousglial activationglial cell activationinjuredinjuriesinjury responseinjury to cellsintra-ocular pressurenecrocytosisnerve injurynerve transectionneural degenerationneural injuryneurochemicalneurochemistryneurodegenerationneurodegenerativeneurological degenerationneuron injuryneuronal degenerationnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachocular diseaseocular disorderocular hypertensiveocular traumaophthalmopathypharmacologicpreservationpreventpreventingreceptive fieldreceptorreceptor expressionreceptor upregulationresponseresponse to injuryretinal ganglionretinal ganglion cell degenerationsocial rolestrokedstrokessynapseuptakevision impairmentvision lossvisual dysfunctionvisual field defectvisual functionvisual lossvisual motorvisually impairedvisuomotor
Description preview
Impaired vision and blindness due to acute and chronic ocular injury and disease, including glaucoma, optic
nerve stroke, and ocular and head trauma have dramatic consequences on the Veteran’s quality of life. Visual
dysfunctions including visual field defects, loss of acuity and blindness are associated with retinal ganglion cell
(RGC)…
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