grant
Sulfide metabolism and signaling
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jan 2019Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025Active SitesAffinityAllosteric RegulationAutoregulationBiochemicalBiogenesisBiologyBiosensorBrain PathologyCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCell Communication and SignalingCell SignalingCell modelCellular modelChemicalsCitric Acid CycleClinicalClustered Regularly Interspaced Short Palindromic Repeats interferenceColorectal CancerDNA mutationDataDehydrogenasesDietDiseaseDisorderElectron TransportElectronsEnergy ExpenditureEnergy MetabolismEpitheliumFoundationsFumaratesFunding MechanismsGI microbiotaGastrointestinal microbiotaGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGenotypeHealthHomeostasisHydrogen SulfideHypoxiaHypoxicIntermediary MetabolismIntracellular Communication and SignalingKrebs CycleL reuteriL. reuteriLaboratoriesLactobacillus reuteriLeigh DiseaseLeigh SyndromeLipidsMembrane PotentialsMetabolicMetabolic ProcessesMetabolismMethionineMiceMice MammalsMicroscopicMitochondriaModelingMolecularMonitorMorphologyMurineMusMutationNegative Beta ParticleNegatronsO elementO2 elementOrigin of LifeOxidation-ReductionOxidoreductaseOxidoreductase GeneOxygenOxygen DeficiencyPhysiological HomeostasisPhysiologyPlastic EmbeddingPoisoningQuinone CompoundQuinonesRNA SeqRNA sequencingRNAseqReactionRedoxReductasesRespirationResting PotentialsS elementSignal TransductionSignal Transduction SystemsSignalingSubacute Necrotizing EncephalomyelitisSubacute Necrotizing EncephalomyelopathySubacute Necrotizing EncephalopathySulfidesSulfurTCA cycleTechniquesToxic effectToxicitiesTransmembrane PotentialsTricarboxylic Acid CycleTumor BurdenTumor Loadaerobic glycolysisbiological sensorbiological signal transductioncarboxylationcofactorcomplex IVdietarydietselectron transferenteric microbial communityenteric microbiotaenzyme pathwayflexibilityflexiblegastrointestinal microbial floragenome mutationgut communitygut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microflorainnovateinnovationinnovativeintestinal epitheliumintestinal floraintestinal microbesintestinal microbiotaintestinal microfloraintestinal tract microfloralive cell imagelive cell imaginglive cellular imagelive cellular imagingmetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial compositionmicrobial hostmitochondrialmitochondrial membranemultiomicsmultiple omicsoxidationoxidation reduction reactionpanomicspoisonedprogramsrepressing CRISPR-dCas9 systemrespiratory mechanismresponsetranscriptome sequencingtranscriptomic sequencingvapor
Description preview
The liminal zone between host epithelium and gut microbiota is rich in sulfide conversations that
are modulated by diet; their short- and long-range impacts on systemic H2S homeostasis
represent a largely unexplored terrain ripe for discovery. The toxicity of H2S, first described as a
noxious “acidic vapor” some 500 years ago, results from its…
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