grant
Studying the function of human genetic variation in the light of 3D genome organization
Organization LA JOLLA INSTITUTE FOR IMMUNOLOGYLocation LA JOLLA, UNITED STATESPosted 1 Aug 2018Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAllelesAllelomorphsAssayAutoimmune DiseasesBioassayBiologicalBiological AssayBiological FunctionBiological ProcessCalibrationCancersCell BodyCellsChromatin LoopChromatin Loop DomainsComplexComputer AnalysisComputing MethodologiesCoupledDNA LoopDNA SequenceDataDimensionsDiseaseDisease OutcomeDisorderEnvironmental FactorEnvironmental Risk FactorGWA studyGWASGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene variantGenetic DiversityGenetic VariationGenomeGenomic SegmentGenotypeGoalsHumanHuman GeneticsHuman GenomeImmuneImmunesIndividualInfectionInvestigatorsKnowledgeLeadMalignant NeoplasmsMalignant TumorMapsMeasurableMethodsMindModalityModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryOutcomePb elementPhenotypeRegulatory ElementRejuvenationResearch PersonnelResearchersResolutionRoleSpecificityTechniquesTranslatingVariantVariationallelic variantautoimmune conditionautoimmune disorderautoimmunity diseasebiologiccausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typecomparativecomputational analysescomputational analysiscomputational methodologycomputational methodscomputer analysescomputer based methodcomputer methodscomputing methodconformationconformationalconformational stateconformationallyconformationsdisease riskdisorder riskenvironmental riskflexibilityflexiblegenetic variantgenome segmentgenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-wide analysisgenome-wide identificationgenomewide association scangenomewide association studygenomic regiongenomic variantheavy metal Pbheavy metal leadhuman whole genomemalignancymethod developmentneoplasm/cancerprogramsresolutionssocial rolethree dimensionalwhole genome association analysiswhole genome association study
Description preview
Abstract
The search for causal genetic variants associated with specific diseases among many variants identified by
genome-wide association studies (GWAS) has been rejuvenated several times by the increase in throughput,
resolution and the number/modality of experimental techniques that are broadly available. Advances in capturing…
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