grant
Study the role of ICOS on murine and human ILC2s
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 11 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAffectAirway DiseaseAirway Hyper-responsivenessAllergensAllergic DiseaseAllergic asthmaAllergyAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAsthmaAutoimmune DiseasesAutomobile DrivingAutoregulationB Cell Differentiation Factor IB cell growth factor 2B-Cell Growth Factor-IIBCGF-IIBCGF2Basal Transcription FactorBasal transcription factor genesBi-specific antibodiesBifunctional AntibodiesBindingBioenergeticsBispecific AntibodiesBlocking AntibodiesBronchial AsthmaCD28CD28 geneCSIFCSIF GeneCSIF-10Cell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell secretionCellsCellular FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessCellular SecretionChIP SequencingChIP-seqChIPseqChronicClinicalClinical TrialsComplementComplement ProteinsConsumptionCytokine Synthesis Inhibitory FactorCytokine Synthesis Inhibitory Factor GeneD-GlucoseDNADNA MethylationDataDeoxyribonucleic AcidDevelopmentDextroseDiseaseDisorderEffector CellEo-CSFEosinophil Differentiation FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperimental ModelsExtrinsic asthmaFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeneral Transcription Factor GeneGeneral Transcription FactorsGlucoseGlycolysisGoalsHealthHealth Care CostsHealth CostsHomeostasisHumanIL-10IL-10 GeneIL-13IL-5IL10IL10 geneIL10AIL10A GeneIL13IgA enhancing factorImmuneImmunesImmunityInflammatoryInterleukin 10 PrecursorInterleukin 10 Precursor GeneInterleukin 5 PrecursorInterleukin-10Interleukin-10 GeneInterleukin-13Interleukin-5Intermediary MetabolismInterventionIntracellular Communication and SignalingLaboratoriesLigandsLungLung InflammationLung Respiratory SystemLymphoid CellMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModern ManMolecularMolecular InteractionMonitorMorbidityMorbidity - disease rateMurineMusPBMCPathogenesisPathway interactionsPatientsPeripheral Blood Mononuclear CellPhenotypePhysiological HomeostasisPlayPneumologyPneumonitisPneumonologyPopulationProductionPublishingPulmonary InflammationPulmonary MedicinePulmonologyRecombinantsRegulatory T-LymphocyteReportingResearch SpecimenResolutionRoleScientistSeveritiesSignal InductionSignal TransductionSignal Transduction SystemsSignalingSourceSpecificitySpecimenSteroid therapySubcellular ProcessT cell replacing factorT-Cell ActivationT-Cell Replacing FactorT-CellsT-LymphocyteT44TGIF GeneTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesTregactivate T cellsairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityatopic asthmaautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductionbsAbcell metabolismcellular metabaolismchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic inflammatory diseasecohortcombinatorialcomplementationcytokinedesigndesigningdevelopmentaldrivingepigeneticallyexperienceextrinsic allergic asthmaflow cytophotometrygain of functionhumanized micehumanized mousein vivoinducible expressioninducible gene expressionmetabolism measurementmetabolomicsmetabonomicsmitochondrialmouse modelmurine modelnoveloverexpressoverexpressionpathwayprogramspulmonaryregulatory T-cellsresolutionsresponsesocial rolethymus derived lymphocytetranscription factortranscriptomicstranslation strategytranslational approachtranslational strategy
Description preview
SUMMARY
The long-term goal of this study is to increase our understanding of the immune mechanisms involved in the
pathogenesis of allergic diseases and asthma. Allergic asthma is a chronic inflammatory disorder that is
characterized by airway hyperreactivity (AHR) and driven by Th2 cytokine production. Group 2 innate lymphoid
cells (ILC2s)…
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