grant
Study epigenetic inheritance during development, homeostasis and regeneration
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 May 2018Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAutoregulationBiological FunctionBiological ProcessBiologyCancersCannot achieve a pregnancyCell BodyCell DifferentiationCell Differentiation processCell divisionCellsChromatinCommunitiesComplexDNA SequenceDegenerative DisorderDegenerative Neurologic DisordersDevelopmentDevelopmental BiologyDiabetes MellitusDifficulty conceivingDiseaseDisorderDrosophilaDrosophila genusEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFailureFertilized EggFertilized OvumGI Stem cellGene ExpressionGenetic MaterialsGerm LinesHereditaryHistonesHomeostasisInfertilityInheritedM PhaseMalignant NeoplasmsMalignant TumorMeiosisMethodsMitosisMitosis StageMuscular DystrophiesMyodystrophicaMyodystrophyNatural regenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOrganismPhysiological HomeostasisPlayProgenitor CellsRegenerationRegenerative MedicineRoleSeriesSystemTherapeuticadulthoodcell behaviorcell typecellular behaviorcellular differentiationdaughter celldegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiabetesepigenetic memoryepigenetic regulationepigeneticallyfertility cessationfertility lossfruit flygastrointestinal stem cellgene functiongene locusgenetic locusgenomic locationgenomic locusgerm stem cellsgermline progenitorgermline progenitor cellsgermline stem cellsgut progenitorgut stem cellin vivoinfertileinsightintestinal progenitorintestinal stem cellsliving systemmalemalignancymeioticmuscle dystrophyneoplasm/cancerneuroblastneurodegenerative illnessprogenitor biologyprogenitor cell biologyregeneratesegregationself-renewself-renewalsocial rolestem and progenitor biologystem cell biologystem cellsstem cells in the germlinetoolzygote♂
Description preview
Project Summary/Abstract:
Epigenetics refers to effects on gene expression or function that are inheritable through mitosis
or meiosis without altering the primary DNA sequences. Epigenetic mechanisms play important
roles in regulating cell identity and activity. Failure in appropriate epigenetic regulation leads to
abnormal behaviors of cells,…
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