grant
STUDIES ON FATTY ACID METABOLIZING CYTOCHROME P450 ENZYMES
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AcidsAffinityAmino Acid SequenceAnimal ModelAnimal Models and Related StudiesArachidonic AcidsArchitectureBP homeostasisBP regulationBindingBiochemistryBiological ChemistryBrain TraumaCYP4F11CYP4F11 geneCancer cell lineCancersCatalysisCell FunctionCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular ProliferationCellular biologyCeramidesComplexCrystallographiesCrystallographyCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P-450 OxidaseCytochrome P-450 ReductaseCytochrome P450Cytochrome P450 Family GeneCytochrome P450 ReductaseCytochrome P450, Family 4, Subfamily F, Polypeptide 11Cytochrome P450, Subfamily IVF, Polypeptide 11Cytochrome b-5Cytochromes b5DiseaseDisorderDrug TargetingDrugsEC 1.6.2.4EicosanoidsEngineering / ArchitectureEnzyme GeneEnzymesEvaluationFamilyFatty AcidsFerricytochrome b5Ferrihemoprotein P-450 ReductaseFerrihemoprotein P450 ReductaseHumanHuman FigureHuman bodyHydroxylasesHypertensionIndividualInflammatoryIsoformsLigand BindingLipidsMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMedicationMetabolic PathwayMixed Function OxidasesMixed Function OxygenasesModern ManMolecular InteractionMonooxygenasesNADPH Cytochrome P-450 OxidoreductaseNADPH Cytochrome P-450 ReductaseNADPH Cytochrome P450 OxidoreductaseNADPH Cytochrome c ReductaseNADPH-Cytochrome P450 ReductaseNADPH-Ferrihemoprotein ReductaseNADPH-P450 ReductaseNADPH-Specific Cytochrome C ReductaseOxidation-ReductionP450Pharmaceutical PreparationsPhysiologyPrimary Protein StructureProductionPropertyProtein IsoformsProteinsPulmonary CancerPulmonary malignant NeoplasmRecombinantsRedoxResearchRoentgen RaysRoleStructureSubcellular ProcessSubstrate SpecificitySynchrotronsTraumatic Brain InjuryVascular Hypertensive DiseaseVascular Hypertensive DisorderVitamin KX-RadiationX-Ray RadiationX-rayXenobiotic MetabolismXrayblood pressure homeostasisblood pressure regulationcell biologycell motilitydisease modeldisorder modeldrug clearancedrug metabolismdrug/agenthigh blood pressurehuman diseasehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinhibitorknock-downknockdownlipid mediatorlipidomicslung cancerlung cancer cellmalignancymodel of animalneoplasm/canceroverexpressoverexpressionoxidation reduction reactionprotein sequenceregulate BPregulate blood pressureresearch visionsocial roletranscriptomicstraumatic brain damagevitamin metabolism
Description preview
PROJECT SUMMARY AND ABSTRACT
Cytochrome P450 enzymes (P450, CYP) are essential for the metabolism of xenobiotics and endobiotics. The
CYP4F family of fatty acid -hydroxylases consists of the isoforms CYP4F2, CYP4F3A, CYP4F3B, CYP4F11,
and CYP4F22 which share amino acid sequence identities up to 93%. All of these isoforms assume different…
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