grant
Studies of Ocular inflammation: Clinical & Translational Research
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025Adrenal Cortex HormonesAffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnteriorAssayBasic ResearchBasic ScienceBioassayBiologicalBiological AssayBlindnessBody TissuesCategoriesCell BodyCellsCellular Immune FunctionChronic CyclitisClinicalClinical MarkersClinical ResearchClinical StudyCorticoidsCorticosteroidsDiagnosticDiseaseDisease remissionDisorderDrugsEnrollmentFailureFlareFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGI microbiomeGI microbiotaGastrointestinal microbiotaGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGoalsHumanIMiDImmuneImmune modulatory therapeuticImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInflammationInflammatoryIntermediate UveitisIntervention StrategiesLaboratoriesLocationManuscriptsMediatingMedicationModern ManMolecularMolecular FingerprintingMolecular ImmunologyMolecular ProfilingPBMCPanuveitisParticipantPathogenesisPatientsPeripheral Blood Mononuclear CellPharmaceutical PreparationsPhenotypePilot ProjectsPosterior UveitisPrediction of Response to TherapyPreparationPrognosisProteomicsRNA SeqRNA sequencingRNAseqRemissionRoleSamplingSightSingle cell seqTechniquesTherapeuticTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranslational ResearchTranslational ScienceTreatment ProtocolsTreatment RegimenTreatment ScheduleUndifferentiatedUveitisVisionactive methodactive techniqueactive treatmentage associatedage correlatedage dependentage linkedage relatedage specificanalyze gene expressionarmbiobankbiologicbiorepositoryclinical biomarkersclinical subtypesclinically useful biomarkerscohortcommensal floracommensal microbescommensal microbiotacommensal microfloradigestive tract microbiomedrug/agentenrollenteric microbial communityenteric microbiomeenteric microbiotaepigenomicsfecal sampleflow cytophotometrygastrointestinal microbial floragastrointestinal microbiomegene expression analysisgene expression assaygut communitygut dysbiosisgut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehealthy volunteerhigh dimensionalityhigh riskhuman diseaseimmune functionimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulatory agentsimmune modulatory drugsimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsimprovedinnovateinnovationinnovativeintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloramicrobialmicrobiomemodel of animalmolecular profilemolecular signaturepatient centeredpatient orientedpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpilot studypredict therapeutic responsepredict therapy responsepreparationsprognosis biomarkerprognosis markerprogramsprospectiveresponse to therapyresponse to treatmentsingle cell next generation sequencingsingle cell sequencingsocial rolestandard of carestool samplestool specimensystemic autoimmune diseasesystemic autoimmune disordertherapeutic responsetherapy predictiontherapy responderstherapy responsetranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation researchtranslation strategytranslational approachtranslational investigationtranslational strategytreatment predictiontreatment responderstreatment responsetreatment response predictiontreatment responsivenessunnecessary treatmentvision lossvisual functionvisual loss
Description preview
Uveitis/Intraocular Inflammatory Disease BioBank (iBank) (16-EI-0046)
Uveitis is a heterogenous group of diseases where the common denominator is the inflammation in the uveal tissues. While less than half may have associated (other) systemic autoimmune diseases more than half remains undifferentiated. The disease course is unpredictable with…
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