grant

Studies of Global Signal Transduction

Organization CORNELL UNIVERSITYLocation ITHACA, UNITED STATESPosted 1 Jan 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20263-D structure3-dimensional structure3D structureATP-protein phosphotransferaseAddressAreaBacteriaBiochemicalBiogenesisBiological FunctionBiological ProcessBiologyCDC42 HomologCancersCell AgingCell BodyCell Communication and SignalingCell Division Cycle 42 ProteinCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell PolarityCell ProcessCell SenescenceCell SignalingCell SurvivalCell ViabilityCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular AgingCellular ExpansionCellular FunctionCellular GrowthCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular RegulationCellular SenescenceCellular biologyCloningCommunicable DiseasesComplexCuesDevelopmentDiseaseDisorderEGF ReceptorEGFRERBB ProteinES cellES cell differentiationESC differentiationEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEvolutionFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2G-ProteinsG25K ProteinGTP-Binding ProteinsGTP-Regulatory ProteinsGlnGlutamineGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHER1HumanInfectious DiseasesInfectious DisorderIntermediary MetabolismIntracellular Communication and SignalingKinase Family GeneKnowledgeL-GlutamineLaboratoriesLinkMacromolecular Protein ComplexesMalignant CellMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMediatingMembraneMessenger RNAMetabolicMetabolic ProcessesMetabolismModern ManMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMultiprotein ComplexesNeuronal DifferentiationOrganismOrigin of LifePhysiologyPlayProcessProtein KinaseQ LevoglutamideQ. LevoglutamideRAFT1RNA SplicingReceptor ProteinRegulationRegulatory ProteinReplicative SenescenceResearchRoleSeriesSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSmall G-ProteinsSmall GTPasesSplicingSubcellular ProcessTGF-alpha ReceptorTherapeutic InterventionTransforming Growth Factor alpha ReceptorUpregulationUrogastrone ReceptorYeastsbiological signal transductionc-erbB-1c-erbB-1 Proteincancer cellcancer survivalcdc42 GTP-Binding Proteincdc42 Proteincell biologycell growthcell growth regulationcell motilitycellular polaritydevelopmentaldifferentiation in embryonic stem cellsembryo derived stem cellembryonal stem cellsembryonic precursor differentiationembryonic progenitorembryonic stem cellembryonic stem cell differentiationerbB-1erbB-1 Proto-Oncogene ProteinerbBlextracellular vesiclesgenetic regulatory proteinglycogen synthase a kinasehydroxyalkyl protein kinaseinsightintercellular communicationinterdisciplinary approachintervention therapyliving systemmRNAmTORmalignancymammalian target of rapamycinmembrane structuremultidisciplinary approachneoplasm/cancernovelp21 cdc42phosphorylase b kinase kinaseprogenitor cell functionprogenitor functionprogramsprotein complexproto-oncogene protein c-erbB-1receptorregulatory gene productreplicative agingsocial rolestem and progenitor cell functionstem and progenitor functionstem cell functionstem cell of embryonic originthree dimensional structure
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Description preview

Abstract: Research in my laboratory has centered on the development and application of multi-disciplinary
approaches to study signal transduction pathways important in normal physiology and, when de-regulated,

contribute to a number of diseases. This began with our discovery and cloning of a novel signaling partner for

the epidermal growth factor…

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