grant
Studies of amplification in rhabdomyosarcoma
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY202512q1313q141p36Allelism TestAssayBasal Transcription FactorBasal transcription factor genesBehaviorBindingBinding SitesBioassayBiologic ModelsBiologicalBiological AssayBiological ModelsCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancersCandidate Disease GeneCandidate GeneCas nuclease technologyCationsCell BodyCell Culture SystemCell LineCellLineCellsChIP SequencingChIP-seqChIPseqChemicalsChildhoodClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCombining SiteComplementary DNAComplementation TestDNA BindingDNA Binding InteractionDNA boundDataData SetDideoxy Chain Termination DNA SequencingDistalElementsEmbryonic Muscle CellsEventFKHRFOXO1FOXO1AFOXO1A geneForkhead Box O1AForkhead in RhabdomyosarcomaFunctional RNAGene ChipsGene Expression ChipGene TranscriptionGeneChipGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic Complementation TestGenetic HeterogeneityGenetic TranscriptionGenomicsGoalsGrowthHUP1HUP2HourHumanImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodKnock-outKnockoutMYCNMYCN ProteinMYCN geneMalignant NeoplasmsMalignant TumorMapsMediatingMiceMice MammalsMicroRNAsModel SystemModern ManMolecularMolecular InteractionMurineMusMyoblastsN-Myc ProteinNMYCNMYC GeneNMYC Gene ProductNeuroblastoma MYCNon-Polyadenylated RNANoncoding RNANontranslated RNAOncogene ProductsOncogene ProteinsOncogenesisOncogenicOncoproteinsPAX3PAX3 genePAX7PAX7 genePaired Box Gene 3Paired Box Gene 7Paired Box Homeotic Gene 7Paired Domain Gene 7Paired Domain Gene HuP2PathogenesisPathway interactionsPhenotypePost-Transcriptional Gene SilencingPrecursor Muscle CellsProcessProliferatingProteinsRNARNA ExpressionRNA Gene ProductsRNA InterferenceRNA SeqRNA SilencingRNA sequencingRNAiRNAseqReactive SiteReagentRecurrenceRecurrentRegulatory ElementRhabdomyosarcomaRibonucleic AcidRoleSanger SequencingSequence-Specific Posttranscriptional Gene SilencingSiteSpecificityStrains Cell LinesTherapeutic InterventionTissue ArraysTissue ChipTissue GrowthTissue MicroarrayTrans TestTranscriptTranscriptionTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTranscriptional ControlTranscriptional RegulationUntranslated RNAUpregulationWS1Western BlottingWestern ImmunoblottingbiologiccDNAcandidate identificationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcomplementation analysiscomplementation approachcultured cell linedirected attentiondirects attentionexperimentexperimental researchexperimental studyexperimentsexpression arrayfusion genegene expression microarraygene interactiongenome scalegenome-widegenomewideintervention therapyknock-downknockdownlive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymiRNAneoplasm/cancernoncodingontogenyoverexpressoverexpressionpathwaypediatricprotein blottingresearch studysocial rolesoft tissuetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettranscription factortranscriptome sequencingtranscriptomic sequencingtumortumorigenesis
Description preview
In our early studies of gene ampli?cation in fusion-positive (FP) rhabdomyosarcoma (RMS), we identi?ed MIR17HG as a key target of the 13q31 amplicon. MIR17HG is a "host gene" in which six microRNAs (miRNAs) (including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a-1) are processed from the RNA transcribed from an intronic region. We…
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