grant
Structure-Function Studies of Apolipoprotein B100
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 24 Mar 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026ASCVDAddressApo-BApoBApolipoproteinsApolipoproteins BArchitectureAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutomobile DrivingBindingBiophysicsBlood SerumBody TissuesCardiovascular DiseasesCatalogingCholesterolCholesterol HomeostasisCommunitiesComplementComplement ProteinsComplexComputer ModelsComputerized ModelsDNA mutationDevelopmentDiabetes MellitusDiseaseDisorderElectron MicroscopyEngineering / ArchitectureGene variantGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationHealthHereditaryHeterogeneityHumanIndividualInheritedIntermediary MetabolismKnowledgeLDLLDL LipoproteinsLipid BiochemistryLipid TraffickingLipidsLipoproteinsLiverLow-Density LipoproteinsMeasuresMembraneMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMethodsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutationOutcomePhenotypePhysiologyPlayPositionPositioning AttributeProteinsReceptor ProteinRecombinantsResearchResearch ResourcesResourcesRoleSeminalSerumStructureStructure-Activity RelationshipSurfaceTechniquesTechnologyThermodynamicThermodynamicsThesaurismosisTissuesallelic variantatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebeta-Lipoproteinsbiophysical foundationbiophysical principlesbiophysical sciencescardiovascular disorderchemical structure functioncholesterol metabolismcomplementationcomputational modelingcomputational modelscomputer based modelscomputerized modelingconformationconformationalconformational stateconformationallyconformationsdensitydevelopmentaldiabetesdrivingexperimentexperimental researchexperimental studyexperimentsfat metabolismgenetic conditiongenetic disordergenetic variantgenome mutationgenomic varianthepatic body systemhepatic organ systeminsightlife-style factorlifestyle factorslipid disorderlipid metabolismlipid transportmembrane structuremetabolism disordermutantnano particlenano-sized particlenanoparticlenanosized particleparticlereceptorreceptor bindingreceptor boundsocial rolestructure function relationshiptomographytooluptake
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Project Summary/Abstract
Lipoproteins (LPs) are heterogeneous macromolecular nanoparticles that play a central role in
transporting lipids and cholesterol between the gut, liver, and other tissues. Apolipoprotein B (apoB), one of the
largest proteins known, serves three main functions: (1) coordinating the synthesis of LP particles; (2) acting as…
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