grant
Structure, function, and mechanobiology of a compression-sensitive cell-cell junction
Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 5 Sept 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3D7B4 Antigen7B4 proteinANK2ANK2 geneActinsAddressAdherens JunctionAdhering JunctionAdhesionsAdhesive JunctionAdultAdult HumanAnchoring JunctionAnimalsAnkyrin 2Ankyrin-BBiologicalBiological FunctionBiological MimeticsBiological ProcessBiologyBiomedical EngineeringBiomimeticsBloodBlood Reticuloendothelial SystemBody TissuesBrain AnkyrinCAP102 proteinCD144 AntigenCRISPRCRISPR/Cas systemCadherinsCell AdhesionCell BodyCell FunctionCell JunctionsCell PhysiologyCell ProcessCell-Cell AdhesionCellsCellular AdhesionCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessClustered Regularly Interspaced Short Palindromic RepeatsComplexCytoskeletal SystemCytoskeletonDevelopmentDiseaseDisorderEndothelial CellsGoalsIn VitroIntercellular JunctionsInterdisciplinary ResearchInterdisciplinary StudyInvestigationInvestigatorsLinkLymphaticLymphatic Endothelial CellsLymphatic functionMaintenanceMechanicsMediatingMediatorMicroscopyMolecularMorphogenesisMultidisciplinary CollaborationMultidisciplinary ResearchNeuronal AnkyrinNonerythroid AnkyrinOrganismOrganization ChartsParticipantPathogenesisPathway interactionsPhysiologicPhysiologicalPhysiologyPlayProcessProteinsRegulationResearch PersonnelResearchersRoleSortingSpectrinStretchingStructureSubcellular ProcessSystemTissuesVE-CadherinVascular Endothelial CadherinVascular Endothelial Cadherin 1adhesion receptoradulthoodalpha E-cateninalpha cateninalpha-1 cateninalphaE cateninbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringcadherin 5cadherin-associated protein 102 kDacell assemblycell typechip modelchip systemdesigndesigningdevelopmentalexperiencegenome editinggenomic editingin vivoin vivo Modelinsightinterdisciplinary approachintermolecular interactioninterstitialintracellular skeletonlive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemlymphatic drainagelymphatic dysfunctionlymphatic impairmentmechanicmechanicalmechanical forcemorphogenetic processmultidisciplinary approachnovelon a chipon chiporgan chiporgan on a chiporgan on chiporganizational structurepathwaypressureresponsescaffoldscaffoldingsocial rolesuperresolution microscopythree dimensionaltoolα-cateninαE-catenin
Description preview
Project Description and Summary
The goal of this proposal is to characterize a newly identified cadherin-mediated cell-cell junction, and
understand the contexts in which it functions. The cooperation between adhesions and mechanical forces is a
central regulator of many developmental and homeostatic processes that has been studied for over half a…
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