grant
Structure and Mechanism of G-proteins and cell adhesion proteins in regulation of cell growth and motility
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Feb 2020Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025ActinsAdhesion MoleculeAdhesionsAffectBeliefBindingBiochemicalCAP102 proteinCancersCardiac defectCardiovascular DiseasesCell Adhesion Molecule GeneCell Adhesion MoleculesCell Adhesion ProcessCell Communication and SignalingCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell ShapeCell SignalingCellular FunctionCellular MatrixCellular MigrationCellular MorphologyCellular MotilityCellular PhysiologyCellular ProcessCellular RegulationCellular biologyCytoskeletal SystemCytoskeletonDNA mutationDiseaseDisorderF-ActinFilamentous ActinFosteringFoundationsG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGenetic ChangeGenetic defectGenetic mutationGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanine NucleotidesGuanosine PhosphatesHeterotrimeric G-ProteinsHeterotrimeric GTP-Binding ProteinsIndividualIntracellular Communication and SignalingInvestigationIsoformsKinasesLipidsMalignant NeoplasmsMalignant TumorMediatingMethodologyMolecularMolecular InteractionMorphologyMutationNucleotidesPathologyPhosphotransferase GenePhosphotransferasesProtein IsoformsProteinsRAS Superfamily ProteinsRas-Related ProteinRegulationResearchRoleSignal TransductionSignal Transduction SystemsSignalingSiteStructureSubcellular ProcessTherapeutic InterventionTransmissionTransphosphorylasesVinculinalpha E-cateninalpha cateninalpha-1 cateninalphaE cateninbiological signal transductioncadherin-associated protein 102 kDacardiovascular disordercell adhesion proteincell biologycell growth regulationcell morphologycell motilitygenome mutationheart defectimproved outcomeinsightinterdisciplinary approachintervention therapyintracellular skeletonmalignancymechanical cuemechanical signalmetavinculinmigrationmonomermultidisciplinarymultidisciplinary approachneoplasm/cancernovelprecision medicineprecision-based medicineprotein activationsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttransmission processα-cateninαE-catenin
Description preview
Abstract
The presented project is a comprehensive investigation encompassing two primary themes. The
first theme revolves around the exploration of novel mechanisms governing the activation and
signaling of guanine nucleotide-binding (G)-proteins, with a particular focus on the RAS
superfamily and heterotrimeric Gα-proteins. Departing from…
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