grant
Structure and function of phospholipids and inositol phosphates in the nucleus.
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 5 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025AddressAllelism TestAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsBindingBiologic ModelsBiological ModelsBiologyCPF geneCPF proteinCYP7A Promoter-Binding FactorCancersCell BodyCell Communication and SignalingCell Membrane LipidsCell NucleusCell SignalingCellsCeramidesChemicalsComplementation TestCytoplasmDiabetes MellitusEnzyme GeneEnzymesFTF geneFTF proteinFundingGene ExpressionGene TranscriptionGenesGeneticGenetic Complementation TestGenetic TranscriptionGoalsHB1FHDAC3HDAC3 enzymeHDAC3 geneHistone AcetylationHumanHuman B1-Binding FactorInositol PhosphatesIntracellular Communication and SignalingKinasesKnock-outKnockoutLRH1LengthLipidsLiver Receptor Homolog 1Major TranquilizersMajor Tranquilizing AgentsMalignant NeoplasmsMalignant TumorMembraneMembrane LipidsMetabolicModel SystemModelingModern ManMolecular InteractionNR5A2NR5A2 geneNeuroleptic AgentsNeuroleptic DrugsNeurolepticsNuclearNuclear Receptor Subfamily 5, Group A, Member 2NucleoplasmNucleusPhosphatidesPhospholipidsPhosphotransferase GenePhosphotransferasesPositionPositioning AttributePropertyRNA ExpressionRPD3-2Receptor ProteinRoleSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSphingolipidsSphingomyelinsStructureTrans TestTranscriptionTransphosphorylasesWorkbiological signal transductioncomplementation analysiscomplementation approachdiabetesfetoprotein transcription factorfunctional genomicshistone deacetylase 3human diseaseinhibitorinositol polyphosphate multikinaseinterestmIPMKmalignancymembrane structureneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategyreceptorscreeningscreeningsside effectsmall moleculesocial rolestructural biologytherapeutic agent developmenttherapeutic developmenttool
Description preview
Summary: Phospholipids and inositol phosphates are two classes of small molecules with well-known
functions in the cytoplasm, but poorly defined roles in the nucleus. The goal of my diverse group is to
understand the structural biology and functional genomics of these two classes of small molecules. We also
take chemical biology approaches to…
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