grant
Structure and Function of Pentameric Ligand-gated Ion Channels
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 21 Jan 2020Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20255-HT5-HT-35-HT3R5-Hydroxytryptamine5-Hydroxytryptamine (Serotonin) Receptor 3A Gene5-Hydroxytryptamine (Serotonin) Receptor-3 Gene5-Hydroxytryptamine 3 Receptor Gene5-Hydroxytryptamine Receptor 3A Gene5HT5HT3RArchitectureBindingCNS Nervous SystemCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCentral Nervous SystemCryo-electron MicroscopyCryoelectron MicroscopyDrug ModulationDysfunctionElectron CryomicroscopyElectrophysiologyElectrophysiology (science)Engineering / ArchitectureEnteramineEnvironmentEventFunctional disorderGastrointestinal DiseasesGlycine ReceptorsGoalsHTR3HTR3AHTR3A geneHippophaineIon Channel GatingIon Channel GatingsKnowledgeLigandsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMediatingMental disordersMental health disordersMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMotorNerve Transmitter SubstancesNervous System DiseasesNervous System DisorderNeural TransmissionNeuraxisNeurologic DisordersNeurological DisordersNeurophysiology / ElectrophysiologyNeurotransmittersOrganism-Level ProcessOrganismal ProcessPainPainfulPeripheral Nervous SystemPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPhysiopathologyPost-Translational RegulationPosttranslational RegulationProtein DynamicsPsychiatric DiseasePsychiatric DisorderReceptor ProteinResearchSerotoninSerotonin 5-HT-3 Receptor GeneSerotonin-Gated Ion Channel Receptor GeneStructureSubcellular ProcessSynapsesSynapticSynaptic TransmissionTechniquesTherapeutic AgentsTherapeutic UsesTransmissionWorkaddictionaddictive disorderchronic painconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydesensitizationdesigndesigningdrug developmentelectrophysiologicalgastrointestinal disordergastrointestinal functionmembermental illnessmolecular dynamicsmultidisciplinaryneurological diseasenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypain perceptionpathophysiologyprogramspsychiatric illnesspsychological disorderreceptorsynapsetherapeutic targettransmission process
Description preview
PROJECT SUMMARY/ABSTRACT
The overarching objectives of this research program are to determine the molecular basis of allosteric
mechanisms that govern gating and modulation in pentameric ligand-gated ion channels (pLGICs). The pLGIC
superfamily governs crucial physiological processes such as gastrointestinal functions, motor coordination, and
pain…
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