grant
Structure, Accessibility and Extension of Telomeric Overhangs
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAgeApoptosisApoptosis PathwayCancersCell BodyCellsCharacteristicsChromosomesComplexComputer ModelsComputerized ModelsCryo-electron MicroscopyCryoelectron MicroscopyDNA DamageDNA InjuryDrugsElectron CryomicroscopyEnsureEnzyme ActivationFRETFluorescenceFluorescence Resonance Energy TransferFrustrationFörster Resonance Energy TransferG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAHumanKineticsLengthMacromolecular Protein ComplexesMalignant NeoplasmsMalignant TumorMedicationMethodsModelingModern ManMonte Carlo MethodMonte Carlo algorithmMonte Carlo calculationMonte Carlo procedureMonte Carlo simulationMultiprotein ComplexesNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNon-Polyadenylated RNANucleic Acid ProbesPatternPharmaceutical PreparationsPhysiologicPhysiologicalPlayProgrammed Cell DeathProteinsRNARNA Gene ProductsRibonucleic AcidRibonucleoproteinsRoleSomatic CellStructureTechniquesTelomeraseTelomere ShorteningTimeWorkadulthoodagesbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescancer typecomputational modelingcomputational modelscomputer based modelscomputerized modelingcryo-EMcryoEMcryogenic electron microscopydrug/agentmalignancyneoplasm/cancerneurological diseasenew approachesnovel approachesnovel strategiesnovel strategynucleaseresponsesenescencesenescentsingle moleculesingle-molecule FRETsingle-molecule fluorescence resonance energy transfersmFRETsmall moleculesocial rolestructural mutationstructural variantstructural variationtelomeretelomere attrition
Description preview
Project Summary: Telomeres contain repeating GGGTTA sequences and terminate with a 50-300 nt long single-stranded
overhang (ssTEL). This overhang folds into tandem G-quadruplex (GQ) structures, which stabilize these otherwise
vulnerable ends and play critical roles in distinguishing them from damaged DNA. In addition, telomeres are protected and…
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