grant
Structural Studies of a T cell Specific Tyrosine Kinase
Organization IOWA STATE UNIVERSITYLocation AMES, UNITED STATESPosted 15 Jan 1999Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AffinityAmino AcidsAntibodiesAntigensAntitumor ResponseAssayAutoimmune DiseasesAutoimmune StatusAutoimmunityAutomobile DrivingAvidityB cell receptorB-Cell Antigen ReceptorBacterial InfectionsBehaviorBesnier-Boeck DiseaseBindingBioassayBiochemicalBiological AssayBoeck's SarcoidBurkitt HerpesvirusBurkitt Lymphoma VirusCD28CD28 geneCD3CD3 AntigensCD3 ComplexCD3 moleculeCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCatalysisCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular ImmunologyCellular PhysiologyCellular ProcessChargeChimera ProteinChimeric ProteinsCo-StimulatorCodeCoding SystemComplexCostimulatorCytokine ReceptorsDNA mutationDataDevelopmentDiseaseDisorderEB virusEBVEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEffector CellEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEpidermal Thymocyte Activating FactorEpstein Barr VirusExpression SignatureFamilyFundingFusion ProteinGene AlterationGene ExpressionGene Expression ProfileGene MutationGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisHHV-4HHV4HealthHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHemophagocytic LymphohistiocytosesHerpes infectionHerpesviridae InfectionsHerpesviridae diseaseHerpesvirus InfectionsHodgkin DiseaseHodgkin DisorderHodgkin lymphomaHodgkin'sHodgkin's LymphomaHodgkin's diseaseHodgkins lymphomaHumanHuman Herpesvirus 4IL-2IL2 ProteinImmune responseImmunityImpairmentIncrease lifespanInfectionInfectious Mononucleosis VirusInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IIIntracellular Communication and SignalingItk proteinKinasesKnowledgeL-ProlineLettersLigandsLinkLymphocyte Mitogenic FactorMalignant Hematologic NeoplasmMalignant LymphogranulomaMalignant NeoplasmsMalignant TumorMediatingMembraneMemoryMissionMitogenic FactorModern ManModificationMolecularMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutationNational Institutes of HealthNatureOKT3 antigenOncogenesisOncogenicOrganismOutcomePH DomainPathway interactionsPatientsPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeripheralPhosphatidesPhospholipidsPhosphorylationPhosphotransferase GenePhosphotransferasesPleckstrin-Homology DomainPoint MutationProcessProlineProtein PhosphorylationProtein Tyrosine KinaseProtein Tyrosine Kinase EEKReactionReceptor SignalingRegulationResearchRlk proteinRoleSH3 DomainsSRC Homology Region 3 DomainSYKSYK geneSarcoidosisSchaumann's DiseaseSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpleen Tyrosine KinaseStimulusStructureSubcellular ProcessT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell growth factorT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell DevelopmentT-Cell Growth FactorT-Cell LymphomaT-Cell Non-Hodgkin's LymphomaT-Cell NonHodgkins LymphomaT-Cell OntogenyT-Cell Stimulating FactorT-Cell and NK-Cell Non-Hodgkin's LymphomaT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell therapeuticsT-cell transfer therapyT-cell-restricted tyrosine kinase TxkT3 AntigensT3 ComplexT3 moleculeT44T8 CellsT8 LymphocytesTEC Protein Tyrosine KinaseTec PTKTec kinaseTec tyrosine kinaseTherapeuticThymocyte Stimulating FactorTransphosphorylasesTsk proteinTumor CellTxk tyrosine kinaseTyrosineTyrosine KinaseTyrosine Kinase DomainTyrosine-Protein Kinase Receptor EEKTyrosine-Protein Kinase SYKTyrosine-Specific Protein KinaseTyrosylprotein KinaseUnited States National Institutes of HealthVariantVariationViral DiseasesVirus DiseasesWorkactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyaminoacidanti-tumor responsearmautoimmune conditionautoimmune disorderautoimmunity diseasebacteria infectionbacterial diseasebiological signal transductionboost longevitycellular differentiationclinical efficacydensitydevelopmentaldrivingelongating the lifespanemt PTKemt protein-tyrosine kinaseenhance longevityexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityfoster longevitygain of functiongene defectgene expression patterngene expression signaturegenome mutationhost responsehuman datahuman diseasehydroxyaryl protein kinaseimmune system responseimmunogenimmunoresponseimprove lifespanimprove longevityimprovedinducible T cell kinaseinsightitk gene productlifespan extensionliving systemmalignancymembrane structuremutant alleleneoplasm/cancerneoplastic cellpMHCpathwaypreventpreventingproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialprolong lifespanprolong longevitypromote lifespanpromote longevityresponsesocial rolesrc Kinasessrc Protein-Tyrosine Kinasessrc Tyrosine Kinasessrc-Family Kinasessrc-Family Tyrosine Kinasesstructural biologysupport longevitytherapeutic T-cell platformthymus derived lymphocytetooltranscriptional profiletranscriptional signaturetumorigenesistyrosyl protein kinaseviral infectionvirus infectionvirus-induced disease
Description preview
Project Summary
T cell development, activation, and differentiation are all dependent on TCR signaling, along with
important contributions from costimulatory and cytokine receptor pathways. Many lines of
evidence indicate that variations in TCR signal strength have a major impact on the outcome of
these processes. For mature CD8 T cells, TCR…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click