grant
Structural Mechanisms of Polycystic Kidney Disease Proteins
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 22 Jul 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ADPKDAdult Polycystic Kidney DiseaseArchitectureAssayAutosomal Dominant Polycystic KidneyAutosomal Dominant Polycystic Kidney DiseaseBiliary AtresiaBindingBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiological MarkersBiologyCationsCell BodyCell Communication and SignalingCell SignalingCell secretionCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular SecretionChemicalsCiliaClassificationComparative StudyComplexCongenital Cardiac DefectsCongenital Heart DefectsCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDefectDevelopmentDiagnosisDiagnosticDiseaseDisease ProgressionDisorderDominant Polycystic Kidney DiseaseELISAElectron CryomicroscopyEngineering / ArchitectureEnzyme-Linked Immunosorbent AssayFamilyFutureGene TranscriptionGenetic ChangeGenetic DiseasesGenetic TranscriptionGenetic defectGenetic mutationGenetics-MutagenesisGoalsHandednessHumanHuman GeneticsIntracellular Communication and SignalingInvestigationIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsIonsKidneyKidney FailureKidney InsufficiencyKidney Urinary SystemLateralityLeadLeftMaintenanceMeasuresMechanicsMediatingMembraneMembrane ChannelsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMendelian diseaseMendelian disorderMendelian genetic disorderMicroRNAsModern ManMolecularMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutateMutationNephronsNucleic AcidsOrganOutcomePathogenicityPathway interactionsPatientsPatternPb elementPlayPolycystic KidneyPolycystic Kidney DiseasesProcessPropertyProtein FamilyProteinsRNA ExpressionRationalizationReceptor ProteinRegulationRenal CellRenal FailureRenal InsufficiencyReportingReproductionRoleSensorySensory ProcessSignal TransductionSignal Transduction SystemsSignalingSiteSitus InversusSpermSperm MotilitySpermatozoaStimulusStructureStructure-Activity RelationshipSurface ProteinsSystematicsTRP channelTesticlesTestisTherapeutic InterventionTimeTranscriptionTransient receptor potential channelTranslatingTubularTubular formationUrineUriniferous Tubebio-markersbiologic markerbiological signal transductionbiomarkercausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantchemical structure functioncryo-EMcryoEMcryogenic electron microscopydevelopmentalenzyme linked immunoassayextracellular vesiclesgenetic associationgenetic conditiongenetic disordergenome mutationheavy metal Pbheavy metal leadheterotaxia syndromeheterotaxyhuman modelinsightintercellular communicationintervention therapyinversion of viscerakidney cellkidney epithelial celllaterality sequencemalemechanicmechanicalmembermembrane structuremiRNAmodel of humanmodel organismmonogenic diseasemonogenic disordernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypharmacologicprognosis biomarkerprognosis markerprognosticprogramsprotein complexreceptorrenalsensorsingle-gene diseasesingle-gene disordersitus abnormalitysitus inversus viscerumsocial rolesperm cellsperm mobilitystoichiometrystructure function relationshipsuccesstherapeutic agent developmenttherapeutic developmenttherapeutically effectivetransposition of visceraurinaryvertebrate embryosvisceral heterotaxyvisceral transpositionvoltagezoosperm♂
Description preview
Project Summary
The human polycystin family of membrane proteins consists of versatile cellular censors classified as PKD1-like
11-transmembrane (TM)-spanning receptors (PKD1, PKD1L1, PKD2L2, and PKDREJ) and PKD2-like 6-TM-
spanning cation channels (PKD2, PKD2L1, and PKD2L2). PKD1 and PKD2 were first identified as the two cul-
prits that are…
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