grant
Structural, mechanical, and cell biological properties of the ciliary zonule
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Jun 2018Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureAffectAgeAgingAntimorphic mutationAssayAtomic Force MicroscopyBioassayBiologicalBiological AssayBiologyBiomechanicsBlood VesselsCataractCell BodyCellsCollagen Lysyl OxidaseCongenital Ectopic LensCutaneous DisorderDNA mutationDermatosesDevelopmentDiagnosisDiseaseDisorderDistantDominant NegativeDominant-Negative MutantDominant-Negative MutationEC 1.4.3.13Ectopia LentisEnzyme GeneEnzymesEpithelial CellsEpitheliumEyeEye diseasesEyeballFBN1FailureFiberFibrillin MicrofibrilsForce MicroscopyFundingGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGlaucomaGleanGoalsGrowthHereditaryHumanImageIn VitroInheritedIntraocular PressureIrisKO miceKnock-out MiceKnockout MiceKnowledgeLeadLeannessLens dislocationLung DiseasesLysyl OxidaseMarfan SyndromeMaterials TestingMeasuresMechanicsMiceMice MammalsModelingModern ManMolecularMurineMusMutationMyopiaNearsightednessNull MouseOcular TensionOpticsPathologyPatientsPb elementPhenotypePhysiologic Intraocular PressurePlayProliferatingPropertyProtein-Lysine 6-OxidaseProteinsProteomePulmonary DiseasesPulmonary DisorderRetinal DetachmentRoleRuptureS PeriodS phaseScanning Force MicroscopyShapesSkin DiseasesSkin Diseases and ManifestationsStaining methodStainsStructureSurfaceSynthesis PeriodSynthesis PhaseSystemTechniquesTensile StrengthTestingThinnessTissue GrowthTransmissionVisualizationWeill-Marchesani syndromeagesbiologicbiomechanicalcataractogenesiscataractous lensescrosslinkcutaneous diseasedermal diseasedermal disorderdevelopmentaldisease of the lungdisorder of the lungextracellulareye disorderfibrillin-1gene nullgenome mutationglaucomatousheavy metal Pbheavy metal leadhuman modelimaginginsightintra-ocular pressurelenslenseslung disordermechanicmechanicalmechanical stimulusmodel of humanmolecular biomarkermolecular markermouse modelmurine modelmutantnear visionnull mutationocular diseaseocular disorderontogenyophthalmopathyopticalpostnatalpressureresponseretina detachmentskin disordersocial rolespatial relationshipthree dimensionalthree dimensional structuretransmission processvascularviscoelasticity
Description preview
Project Summary
The fibers of the ciliary zonule suspend the lens on the optical axis and transmit the forces that flatten it during
disaccommodation. Mutations in genes encoding zonular proteins underlie syndromic and non-syndromic
conditions that affect the eye profoundly. Common ocular phenotypes include ectopia lentis (lens dislocation),…
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