grant
Structural Correlates of (Pro)Cofactor Function
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2018Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AC GlobulinAbscissionAccelerationAcidic RegionActivated Blood Coagulation Factor XActivated Factor XAddressAdoptedAffectAffinityAntibodiesAnticoagulant AgentsAnticoagulant DrugsAnticoagulantsAntigenic DeterminantsAssayAtomic Force MicroscopyAutoantibodiesAutoprothrombin CBindingBinding DeterminantsBinding SitesBioassayBiological AssayBiologyBleedingBlocking AntibodiesBlood ClottingBlood Coagulation DisordersBlood Coagulation FactorBlood Coagulation Factor VBlood PlasmaBlood coagulationChemistryClinicalClottingCoagulationCoagulation DisorderCoagulation Factor VCoagulation Factor XaCoagulation FactorsCoagulation ProcessCoagulopathyCofactor Protein SCombining SiteDNA mutationDataDevelopmentElementsEnsureEpitopesEquilibriumExcisionExtirpationFV LeidenFactor PiFactor VFactor V DeficiencyFactor XaForce MicroscopyGatekeepingGenerationsGenetic ChangeGenetic defectGenetic mutationGoalsHemorrhageHemorrhagic DiathesisHemorrhagic DisordersHemostasisHemostatic AgentsHemostatic functionHemostaticsInjuryKnowledgeLigandsLightMediatingMinorMolecular InteractionMutationOwren DiseaseParahemophiliaPathologicPathway interactionsPatientsPhenotypePhotoradiationPhysiologicPhysiologicalPhysiologyPlasmaPlasma SerumPlayProaccelerinProcessPropertyProtein CleavageProtein SProteinsProteolysisRNA SplicingReactive SiteRegulationRemovalResistanceReticuloendothelial System, Serum, PlasmaRiskRoleScanning Force MicroscopySeriesSplicingStructureSurgical RemovalSystemTestingTexasTherapeuticThrombaseThrombinThrombokinaseThrombosisVariantVariationVitamin K-Dependent Protein SWorkXaseXase complexactivated Protein Cautoimmune antibodyautoreactive antibodybalancebalance functionbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbleeding disorderblood lossblood thinnercancer procoagulantcancer procoagulant Aclotting disorderclotting factorcofactorcofactor CdevelopmentalfXasefactor V G1691Afactor V Leidenfactor X activatorfactor X procoagulantfactor Xasefibrinogenasegatekeepergenome mutationimprovedin vivoinjuriesinjury to the vasculatureinsightintrinsic fXaselabile componentlabile factormouse modelmurine modelneoplasm procoagulant Aneoplastic procoagulantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayprothrombaseprothrombinase complexresectionresistantself reactive antibodysocial rolethrombopoiesis inhibitorthrombotic diseasethrombotic disordertubulin-specific chaperone Ctubulin-specific cofactor Cvascular injury
Description preview
PROJECT 2-PROJECT SUMMARY/ABSTRACT
The coagulation system is tightly regulated to ensures hemostasis is properly achieved following injury. Factor
V (FV) is a crucial component of this system playing both procoagulant and anticoagulant roles. Imbalanced
expression and control of these activities can result in bleeding or thrombosis. Recent work by…
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