grant
Structural characterization of the elongasome and divisome in mycobacteria
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureAddressAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsArchitectureAssayB subtilisB. subtilisBacillus subtilisBacteriaBindingBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiophysicsC-terminalCause of DeathCell BodyCell ComponentsCell Division ProcessCell StructureCell WallCell divisionCellsCellular ExpansionCellular GrowthCellular StructuresCharacteristicsChemicalsChromosome SegregationCommunicable DiseasesComplementComplement ProteinsComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDNA Molecular BiologyDevelopmentDiseaseDisorderDrug resistanceE coliE. coliElectron CryomicroscopyElectron MicroscopyEngineering / ArchitectureEscherichia coliExhibitsGeneralized GrowthGeneticGenus MycobacteriumGrowthHeterogeneityImageImmune PrecipitationImmunoprecipitationIn SituInfectionInfectious DiseasesInfectious DisorderLabelLateralM smegmatisM tbM tuberculosisM tuberculosis infectionM. smegmatisM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacromolecular Protein ComplexesMapsMediatingMethodsMicrobiologyMiscellaneous AntibioticModelingMolecularMolecular BiologyMolecular InteractionMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMultiprotein ComplexesMycobacteriumMycobacterium smegmatisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionPathogenesisPhenotypePolymersPopulationPositionPositioning AttributePredispositionProtein Complex SubunitProteinsProteomicsRegimenResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugResolutionRoleSamplingSiteStructureSusceptibilitySystemTB infectionTB therapyTB treatmentTOMOTechniquesTissue GrowthTomogramTrainingTuberculosisVisualizationWorkbacteria pathogenbacterial disease treatmentbacterial geneticsbacterial infectious disease treatmentbacterial pathogenbiophysical foundationbiophysical principlesbiophysical sciencescell envelopecell growthchromosome divisioncofactorcomplementationcryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydaughter celldesigndesigningdevelopmentaldisseminated TBdisseminated tuberculosisdrug resistantelectron cryo-tomographyexperimentexperimental researchexperimental studyexperimentsimaginginfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinsightlight microscopymortalitymtbmulti-drug resistantmultidrug resistantmutantmycobacterialnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyparticlepathogenpathogenic bacteriapolymerpolymericpreventpreventingprotein complexprotein protein interactionprotein purificationresistance strainresistance to Drugresistant strainresistant to Drugresolutionssocial rolespatial and temporalspatial temporalspatiotemporalstructural biologythree dimensionalthree dimensional structuretreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyz-ring
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Project Summary
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the leading causes of death
due to infectious disease. Antibiotic treatment of Mtb is arduous and multidrug-resistant strains are on the rise,
thus fueling the need for novel therapeutics. During infection, subpopulations of Mtb cells are…
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