grant
Structural characterization of OM proteins from Gram-negative pathogens
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcinetobacterAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAreaBacteriaBacterial Outer Membrane ProteinsBacteriophagesBindingBinding ProteinsBiochemistryBiological ChemistryBlood SerumCapsulesCationsCell BodyCell Communication and SignalingCell SignalingCellsCitratesClinicalCodeCoding SystemColicin IaColicinesCollaborationsCommunicable DiseasesComplexComputer AnalysisCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDataDevelopmentDrug TargetingE coliE. coliElectron CryomicroscopyElectron MicroscopyElectrophysiologyElectrophysiology (science)ElementsEngineeringEnterobactinEnterochelinEscherichia coliFamilyFe elementGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGram-Negative BacteriaH+ elementHumanHuman GenomeHydrogen IonsInfectious DiseasesInfectious DisorderIntegral Membrane ProteinIntracellular Communication and SignalingIntrinsic Membrane ProteinIonsIronK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeLengthLibrariesLigand Binding ProteinLigand Binding Protein GeneLipidsLower OrganismManuscriptsMembraneMembrane Protein GeneMembrane ProteinsMembrane Transport ProteinsMembrane TransportersMembrane-Associated ProteinsMeningococcusMetalsMiscellaneous AntibioticModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMotorMovementMutationN meningitidisN. meningitidisNIAIDNational Institute of Allergy and Infectious DiseaseNatureNeisseriaNeisseria meningitidisNeurophysiology / ElectrophysiologyOMP ProteinsP aeruginosaP. aeruginosaPasteurella pestisPathogenicityPathway interactionsPatient IsolationPeriplasmic SpacePesticinPhagesPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlaguePlasma ProteinsPositionPositioning AttributePreparationProtein BindingProtein EngineeringProtein ImportProteinsProton-Motive ForceProtonsPseudomonas InfectionsPseudomonas aeruginosaPseudomonas pyocyaneaPumpReceptor ProteinRegulationResistance developmentResistance to antibioticsResistant developmentResistant to antibioticsResolutionRoentgen RaysRoleSerumSiderochromesSiderophilinSiderophoresSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSpectroscopySpectrum AnalysesSpectrum AnalysisStructureSurfaceSurface ProteinsSystemToxinTransferrinTransition ElementsTranslatingTransmembrane ProteinTransmembrane Protein GeneVaccinesVirulenceWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray CrystallographyY pestisY. pestisYersinia pestisYersinia pestis diseaseZincZn elementanti-microbialantibiotic drug resistanceantibiotic resistantantimicrobialbacteria pathogenbacterial pathogenbacterial virusbiological signal transductionbody movementbound proteincapsulecolicincomputational analysescomputational analysiscomputer analysesconformationconformationalconformational stateconformationallyconformationscrosslinkcryo-EMcryoEMcryogenic electron microscopydesigndesigningdeveloping resistancedevelopmentaldrug developmentdrug discoveryefflux pumpelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsgenetic protein engineeringgenome mutationhuman whole genomein silicoinsightinterestlysinmembrane structuremolecular dynamicsnano machinenanodisknanomachinenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpathogenic bacteriapathwayperiplasmpharmaceuticalpreparationsprotein complexprotein designprotein structureprotein structuresproteins structurereceptorreceptor bindingreceptor boundresolutionsscreeningscreeningssmall moleculesocial rolestoichiometrysuccesstransition metaluptake
Description preview
Our early crystal structures showed how iron transporters specifically recognize Fe3+ bound to small molecules such as enterobactin (a siderophore synthesized by Escherichia coli) and citrate. Each transporter has a unique binding pocket for its preferred small molecule. When the correct substrate binds, the transporter undergoes conformational…
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