grant
Structural characterization of MCE transport systems from Mycobacterium tuberculosis
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 3 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025Antibiotic AgentsAntibiotic DrugsAntibioticsArchitectureAssayBacteriaBindingBioassayBiochemicalBiological AssayCause of DeathCell BodyCellsCellular MembraneCholesterolCommunicable DiseasesComplexComplex AnalysisCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDevelopmentDrug resistanceE coliE. coliElectron CryomicroscopyEngineering / ArchitectureEnvironmentEscherichia coliFatty AcidsGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGenus MycobacteriumGram-Negative BacteriaGrowthHydrophobicityImmune responseImmune systemIn VitroIndividualInfectious DiseasesInfectious DisorderLearningLinkLipid TraffickingLipidsLungLung Respiratory SystemM smegmatisM tbM tuberculosisM tuberculosis infectionM. smegmatisM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacromolecular Protein ComplexesMacrophageMaintenanceMammalian CellMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMiscellaneous AntibioticModelingMolecular InteractionMultiprotein ComplexesMutationMycobacteriumMycobacterium smegmatisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNutrientOperonPathogenesisPathogenicity FactorsPhagosomesPlanetsPlayProtein FamilyProtein SubunitsProtein TraffickingProteinsProteomicsRoleStructureSystemTB infectionTB therapyTB treatmentTestingTimeTissue GrowthTuberculosisVirulenceVirulence FactorsWorkcell envelopecombatcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldisseminated TBdisseminated tuberculosisdrug resistantgene productgenome mutationhost responseimmune system responseimmunoresponseinfection due to Mycobacterium tuberculosisinsightlipid transportmembrane biogenesismembrane structuremtbmycobacterialontogenyparticlepathogenpolypeptideprotein complexprotein functionprotein protein interactionprotein structureprotein structuresprotein transportproteins structureresistance strainresistance to Drugresistant strainresistant to Drugsocial rolestructural biologytraffickingtreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathy
Description preview
Project Summary/Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the deadliest pathogens
on the planet, and for decades, TB has been the leading cause of death due to infectious disease. The cell
envelope of Mtb forms a notoriously tough barrier around the cell, protecting the bacterium from harsh…
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