grant
structural characterization of bacterial secretion channels
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AdoptedAffinityAntibiotic AgentsAntibiotic DrugsAntibioticsAssayBacteriaBindingBioassayBiochemicalBiogenesisBiological AssayCell BodyCell Communication and SignalingCell SignalingCellsChaperoneCharacteristicsChloroplastsCommunicationComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmDetergentsDiseaseDisorderElectron CryomicroscopyFutureGeneHomologGram-Negative BacteriaHealthHomologHomologous GeneHomologueHumanIn VitroIndividualIntracellular Communication and SignalingLateralLipid BilayersLipidsMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiscellaneous AntibioticMitochondriaMitochondrial PorinModern ManMolecular ChaperonesMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMotionMureinNatureOrigin of LifeOuter Mitochondrial MembranePeptide Signal SequencesPeptidoglycanPeripheralPeriplasmic SpaceProtein BiosynthesisProtein ExportProtein Export PathwayProtein ImportProtein translocationProteinsPublicationsPublishingResearchResolutionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleRotationS thermophilusS. thermophilusScienceScientific PublicationSignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSortingStreptococcus thermophilusStructureSurfaceSurface ProteinsTOM channelTOM complexTOM translocaseTransmembrane Protein TransportVDAC mitochondrial porinVDAC proteinsVoltage-Dependent Anion ChannelWorkWritinganion-selective channels voltage-dependentbeta barrelbiological signal transductionconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopyexperimentexperimental researchexperimental studyexperimentshuman diseaseinsightinterestlipid bilayer membranemembrane biogenesismembrane structuremitochondria porinsmitochondrialmitochondrial dysfunctionmitochondrial pore proteinnano-molarnanodisknanomolarparticlepeptide mimeticpeptide mimicpeptidomimeticsperiplasmpore forming protein VDACprotein signal sequenceprotein synthesisresolutionssmall molecular inhibitorsmall molecule inhibitorsocial rolestructural biologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentvoltage-dependent, anion-selective, channel forming protein, mitochondrial
Description preview
Gram-negative bacteria, mitochondria, and chloroplasts contain an inner and outer membrane. The outer membrane contains a host of beta-barrel proteins commonly called outer membrane proteins (OMPs), which serve essential functions in cargo transport and signaling and are also vital for membrane biogenesis. In Gram-negative bacteria, it is known…
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