grant
Structural basis of apoptotic scrambling
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AffectApoptosisApoptosis PathwayApoptoticAssayAutoimmune DiseasesAutoregulationBindingBioassayBiochemicalBiological AssayBody TissuesC elegansC-terminalC. elegansC.elegansCaenorhabditis elegansCaspaseCaspase GeneCell BodyCell Membrane LipidsCell membraneCell-Death ProteaseCellsChargeComplexCryo-electron MicroscopyCryoelectron MicroscopyCuesCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytoplasmic MembraneDNA Double-Strand Break Repair and V(D)J Recombination Protein XRCC4DNA Repair Protein XRCC4DataDedicationsDimerizationDiseaseDisorderDrug TherapyDysfunctionElectron CryomicroscopyEnvironmentFoundationsFunctional disorderFutureGeneHomologGoalsHomeostasisHomologHomologous GeneHomologueHumanHydrophobicityICE-like proteaseImageImmuneImmune SurveillanceImmunesImmunologic SurveillanceImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosurveillanceIn VitroInvestigationLengthLigandsLinkLipid TraffickingLipidsMeasurementMediatingMembraneMembrane LipidsModelingModern ManModificationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutateNuclearOncogenesisOutcomePathologyPathway interactionsPeptidesPharmacological TreatmentPharmacotherapyPhosphatidylserinesPhosphorylationPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPhysiopathologyPlasma MembranePlayProcessProgrammed Cell DeathProliferatingPropertyProtein DimerizationProtein FamilyProtein PhosphorylationProtein TraffickingProteinsReceptor ProteinRecoveryRegulationResolutionRoleSerine PhosphoglyceridesStructureSurfaceTestingTissuesTumor CellViralVisualizationX-Ray Repair Cross Complementing Protein 4XRCC4XRCC4 geneautoimmune conditionautoimmune disorderautoimmunity diseasebasebasesconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopycystein proteasecystein proteinasecysteine endopeptidasedesigndesigningdrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentshydrophilicityimagingimmune clearanceimmune eliminationimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinflammatory environmentinflammatory milieuinhibitorinsightlipid transportmembermembrane structuremimicrymonomermulti-modalitymultimodalitymutantnanodiskneoplastic cellnonspecific phospholipid transfer proteinsnovelpathogen exposurepathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphospholipid scramblaseplasmalemmapreventpreventingprotein transportreceptorreconstitutereconstitutionresolutionsrestorationsocial roletumorigenesis
Description preview
ABSTRACT
Every day ~50 billion cells undergo apoptosis, or programmed cell death. Efficient recognition and clearance of
these cells is critical for tissue homeostasis in physiology and for its recovery following disease. Initiation of the
apoptotic cascade triggers activation of phospholipid scramblases that externalize the lipid…
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