grant
Structural Basis of APOBEC Functions and HIV Restriction
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Apr 2009Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressBindingBiological FunctionBiological ProcessCancersCell Culture TechniquesCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCholesterol HomeostasisComparative StudyComplementary DNAComplexConflictConflict (Psychology)Cytidine AminohydrolaseCytidine DeaminaseCytosine AminohydrolaseCytosine deaminaseDNADNA VirusesDNA mutationDataDeaminaseDeaminationDeoxyribonucleic AcidDevelopmentDinucleoside PhosphatesDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEnzyme GeneEnzymesEvolutionExhibitsFamilyGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGoalsHBVHIVHIV-1HIV-2HIV-IHIV-IIHIV/AIDSHIV1HIV2HPVHTLV-IVHepatitis B VirusHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus Type 2Human Immunodeficiency VirusesHuman Papilloma VirusHuman PapillomavirusHuman T-Lymphotropic Virus Type IVHuman immunodeficiency virus 1Human immunodeficiency virus 2Hyper IgM syndromeHyperimmunoglobulin M SyndromeImmuneImmunesImmunityImmunodeficiency and CancerInfectionInfectious Human Wart VirusInnate ImmunityKnowledgeLAV-2LAV-HTLV-IIILengthLentivirinaeLentivirusLymphadenopathy-Associated VirusMalignant NeoplasmsMalignant TumorMolecularMolecular InteractionMolecular TargetMuscle DevelopmentMuscular DevelopmentMutateMutationNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNucleic Acid BindingNucleic AcidsOncogenesisPathway interactionsPlayPrimatesPrimates MammalsProteinsRNA ExpressionRegulationRetroelementsRetroviridaeRetrovirusesRiskRoleSIVSequence HomologySimian Immunodeficiency VirusesStructureSubcellular ProcessSubstrate SpecificitySurfaceTherapeutic InterventionTranscriptionUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationViralViral ActivityViral DiseasesViral FunctionViral PathogenesisViral PhysiologyVirionVirusVirus DiseasesVirus ParticleVirus-HIVVirus-Retrovirusacquired immunityarms raceatomic interactionscDNAcell culturecell culturescholesterol metabolismcombatdevelopmentaldinucleotidefightinggenome integritygenome mutationgenomic integrityhypoimmunityimmune deficiencyimmunodeficiencyinnovateinnovationinnovativeinsightintervention therapymalignancymemberneoplasm/cancernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypathwaypreferencerecruitsocial rolesuccesstumorigenesisubiquinationubiquitin conjugationubiquitin-protein ligaseviral RNAviral infectionvirus RNAvirus infectionvirus pathogenesisvirus-induced diseasewart virus
Description preview
APOBEC proteins, a diverse family of cytosine deaminases, are pivotal to multiple biological processes, ranging from innate and acquired immunity to cholesterol metabolism and oncogenesis. Central to their function is the ability to edit nucleic acids, a mechanism exploited to restrict viral infections, including those caused by retroviruses like…
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