grant
Structural Basis and Molecular Mechanism of GPCR-Arrestin Interactions
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025ArrestinsBP homeostasisBP regulationBindingCalciumCell BodyCell Communication and SignalingCell SignalingCellsChemokine Receptor GeneComplexCryo-electron MicroscopyCryoelectron MicroscopyDissectionDrug DesignDrug TargetingDrugsElectron CryomicroscopyEndocrine Gland SecretionG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Kinase FamilyG Protein-Coupled Receptor SignalingG protein coupled receptor kinaseG-Protein-Coupled ReceptorsG-ProteinsGPCRGPCR SignalingGRKGTP-Binding ProteinsGTP-Regulatory ProteinsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGustationHormonesHumanImmune responseInterventionIntracellular Communication and SignalingIonsKinasesMediatingMedicationModern ManMolecularMolecular InteractionMoodsNerve Transmitter SubstancesNeurotransmittersOrganism-Level ProcessOrganismal ProcessPathway interactionsPharmaceutical PreparationsPhosphorylationPhosphotransferase GenePhosphotransferasesPhotonsPhysiologic ProcessesPhysiological ProcessesProtein PhosphorylationPublishingRegulatory ProteinReportingResolutionRetinal S-AntigenSafetySightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureTasteTaste PerceptionTherapeuticTherapeutic HormoneTransducersTransphosphorylasesVisionVisualizationbiological signal transductionblood pressure homeostasisblood pressure regulationchemokine receptorcryo-EMcryoEMcryogenic electron microscopydesigndesigningdrug/agentgenetic regulatory proteingustatory perceptiongustatory processinggustatory responsehost responseimmune system responseimmunoresponseinsightnovelpathwayprotein complexreceptor bindingreceptor boundreceptor functionregulate BPregulate blood pressureregulatory gene productresolutionsresponsetaste processingtaste responsetoolvisual function
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Project Summary/Abstract
G protein coupled receptors are essentially the molecular messengers of the cell,
transducing signals from outside to inside. The signals are remarkably diverse, including a single
photon, ion like calcium, neurotransmitters and hormones. Humans have more than 800 GPCRs
for recognizing different signals, but only three…
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