grant
Structural and Functional Studies of Cell-Adhesion Receptors
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAdhesionsAssayBioassayBiochemicalBiological AssayBiophysicsCancersCell AdhesionCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell Surface ReceptorsCell to Cell Communication and SignalingCell-Cell SignalingCellular AdhesionCellular FunctionCellular PhysiologyCellular ProcessCommunicationCommunitiesComplexDevelopmentDiseaseDisorderDrugsEukaryotaEukaryoteEvolutionFDA approvedFamilyFutureG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGenetic studyGenetics-MutagenesisGoalsHeartIntracellular Communication and SignalingKnowledgeLigandsLinkMalignant NeoplasmsMalignant Nervous System NeoplasmMalignant TumorMediatingMedicationMolecularMutagenesisMutagenesis Molecular BiologyMutateNatureNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersOrganismPharmaceutical PreparationsPhysiologicPhysiologicalProtein EngineeringReceptor ProteinResearchRoleSignal TransductionSignal Transduction SystemsSignalingSkeletal systemStructureSubcellular ProcessTestingTherapeuticWorkadhesion receptorbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbrain deformitybrain malformationcongenital brain anomalycongenital brain deformitydevelopmentaldevelopmental diseasedevelopmental disorderdrug/agentextracellulargenetic protein engineeringhuman diseaseinsightintercellular communicationinterdisciplinary approachliving systemmalignancymalignant nervous system tumormalignant neurologic neoplasmsmultidisciplinary approachneoplasm/cancernervous system developmentneurological cancersneurological diseasenew approachesnovel approachesnovel strategiesnovel strategyprogramsprotein designreceptorreceptor functionsocial rolesuccessthree dimensional structuretool
Description preview
Project Abstract
Cellular communication is essential for the development of all multicellular organisms, and is a key phenomenon
that is disrupted in many human diseases. Cell-surface receptors mediate cellular communication and are the
targets for 50% of FDA-approved drugs, highlighting their disease relevance and druggability. However, many…
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