grant
Structural and functional studies of alphavirus receptors
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 7 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AddressAlpha VirusAlphavirus InfectionsAmericasAnti-viral AgentsAssayAstrocytesAstrocytusAstrogliaBindingBinding ProteinsBioassayBiochemicalBiological AssayBody TissuesBrainBrain InflammationBrain Nervous SystemCase Fatality RatesCell BodyCellsCryo-electron MicroscopyCryoelectron MicroscopyCulicidaeDependenceDiseaseDisease OutbreaksDisorderDomestic HorseDrug or chemical Tissue DistributionDrugsEEE VirusEEEVEastern Equine EncephalitisEastern Equine Encephalitis VirusEastern Equine EncephalomyelitisEastern Equine Encephalomyelitis VirusElectron CryomicroscopyEncephalitisEncephalonEquineEquine SpeciesEquus caballusEquus przewalskiiFDA approvedGroup A ArbovirusesHorsesHortega cellHumanIn VitroInfectionKnowledgeLDLLDL LipoproteinsLR7-8BLRP8 proteinLeftLigand Binding ProteinLigand Binding Protein GeneLow-Density LipoproteinsMedicationMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicrogliaModern ManMolecular InteractionMosquitoesMurineMusNerve CellsNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeurocyteNeurological DamageNeurological InjuryNeurological traumaNeuronsNeuropathogenesisOutbreaksPCDH10PathogenesisPathogenicityPathway interactionsPharmaceutical PreparationsPhysiologicPhysiologicalPropertyProtein BindingProteinsPublic HealthRNA VirusesReceptor CellReceptor ProteinResearchResolutionRoleSecondary toStructureSurface ProteinsTestingTherapeutic InterventionTimeTissue DistributionTissuesTransmissionVEE virusVEEVVLDL receptorVaccinesVenezuelan Equine Encephalitic VirusVenezuelan Equine Encephalitis VirusVenezuelan Equine Encephalomyelitis VirusViral DiseasesViral EncephalitisViral Infectious EncephalomyelitisViral PathogenesisViral ReceptorVirulenceVirusVirus DiseasesVirus ReceptorsVirus-like particleVisualizationWEE VirusWEEVWestern Equine Encephalitic VirusWestern Equine EncephalitisWestern Equine Encephalitis VirusWestern Equine EncephalomyelitisWestern Equine Encephalomyelitis VirusWorkaccess to vaccinationaccess to vaccinesalphavirus receptoranti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsapoER2apolipoprotein E receptor 2apolipoprotein E receptor 2 gene productastrocytic gliabeta-Lipoproteinsbound proteinbrain cellcell typeclimate changeclimatic changescombatcryo-EMcryoEMcryogenic electron microscopydesigndesigningdrug/agentepidemic concernepidemic potentialepidemic riskepidemic threatexperimentexperimental researchexperimental studyexperimentsgitter cellglobal climate changehuman pathogeninhibitorinsightintervention therapylow density lipoprotein receptor-related protein 8mesogliamicroglial cellmicrogliocyteneuronalneurotraumapathwayperivascular glial cellpreventpreventingprotocadherin 10receptorreceptor bindingreceptor boundresolutionssocial roletherapeutic targettransmission processunpublished worksvaccination accessvaccination availabilityvaccine accessvaccine availabilityvery low density lipoprotein receptorsviral infectionvirus infectionvirus pathogenesisvirus-induced diseasevirus-like nanoparticlesviruslike particle
Description preview
ABSTRACT
Alphaviruses are mosquito-transmitted, positive-strand enveloped RNA viruses that cause severe diseases in
humans, including lethal encephalitis. Despite their epidemic potential, there are no FDA-approved antivirals or
vaccines against any alphavirus infection. Infections by certain alphaviruses have increased in recent years,
likely…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click