grant
Structural and functional studies of alphavirus receptors
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 7 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AddressAlpha VirusAlphavirus InfectionsAmericasAnti-viral AgentsAssayAstrocytesAstrocytusAstrogliaBindingBinding ProteinsBioassayBiochemicalBiological AssayBody TissuesBrainBrain InflammationBrain Nervous SystemCase Fatality RatesCell BodyCellsCryo-electron MicroscopyCryoelectron MicroscopyCulicidaeDependenceDiseaseDisease OutbreaksDisorderDomestic HorseDrug or chemical Tissue DistributionDrugsEEE VirusEEEVEastern Equine EncephalitisEastern Equine Encephalitis VirusEastern Equine EncephalomyelitisEastern Equine Encephalomyelitis VirusElectron CryomicroscopyEncephalitisEncephalonEquineEquine SpeciesEquus caballusEquus przewalskiiFDA approvedGroup A ArbovirusesHealthHorsesHortega cellHumanIn VitroInfectionKnowledgeLDLLDL LipoproteinsLR7-8BLRP8 proteinLeftLigand Binding ProteinLigand Binding Protein GeneLow-Density LipoproteinsMedicationMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicrogliaModern ManMolecular InteractionMosquitoesMurineMusNerve CellsNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeurocyteNeurological DamageNeurological InjuryNeurological traumaNeuronsNeuropathogenesisOutbreaksPCDH10PathogenesisPathogenicityPathway interactionsPharmaceutical PreparationsPhysiologicPhysiologicalPropertyProtein BindingProteinsRNA VirusesReceptor CellReceptor ProteinResearchRoleStructureSurface ProteinsTestingTherapeutic InterventionTimeTissue DistributionTissuesTransmissionVEE virusVEEVVLDL receptorVaccinesVenezuelan Equine Encephalitic VirusVenezuelan Equine Encephalitis VirusVenezuelan Equine Encephalomyelitis VirusViral DiseasesViral EncephalitisViral Infectious EncephalomyelitisViral PathogenesisViral ReceptorVirulenceVirusVirus DiseasesVirus ReceptorsVirus-like particleVisualizationWEE VirusWEEVWestern Equine Encephalitic VirusWestern Equine EncephalitisWestern Equine Encephalitis VirusWestern Equine EncephalomyelitisWestern Equine Encephalomyelitis VirusWorkaccess to vaccinationaccess to vaccinesalphavirus receptoranti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsapoER2apolipoprotein E receptor 2apolipoprotein E receptor 2 gene productastrocytic gliabeta-Lipoproteinsbound proteinbrain cellcell typecombatcryo-EMcryoEMcryogenic electron microscopydesigndesigningdrug/agentepidemic concernepidemic potentialepidemic riskepidemic threatexperimentexperimental researchexperimental studyexperimentsgitter cellhigh definitionhigh-resolutionhuman pathogeninhibitorinsightintervention therapylow density lipoprotein receptor-related protein 8mesogliamicroglial cellmicrogliocyteneuronalneurotraumapathwayperivascular glial cellpreventpreventingprotocadherin 10receptorreceptor bindingreceptor boundsocial roletherapeutic targettransmission processunpublished worksvaccination accessvaccination availabilityvaccine accessvaccine availabilityvery low density lipoprotein receptorsviral infectionvirus infectionvirus pathogenesisvirus-induced diseasevirus-like nanoparticlesviruslike particle
Description preview
ABSTRACT
Alphaviruses are mosquito-transmitted, positive-strand enveloped RNA viruses that cause severe diseases in humans, including lethal encephalitis. Despite their epidemic potential, there are no FDA-approved antivirals or vaccines against any alphavirus infection. Infections by certain alphaviruses have increased in recent years. Eastern…
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