grant
Structural and functional definition of human astrovirus-receptor interactions
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 19 Jan 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026Adenosine Deaminase-Binding ProteinsAffectAmino AcidsAnimal ModelAnimal Models and Related StudiesAnti-viral AgentsAnti-viral TherapyAntibodiesAstrovirusBindingBiologyBrain InflammationCD26CD26 AntigensCRISPRCRISPR activationCRISPR activatorCRISPR based activationCRISPR editing screenCRISPR gene activationCRISPR screenCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-based screenCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/Cas systemCRISPR/Cas9 screenCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCaCo2Caco-2 CellsCapsidCell BodyCell Culture TechniquesCell LineCellLineCellsChildhoodClinicalClustered Regularly Interspaced Short Palindromic RepeatsColon AdenocarcinomaColonic AdenocarcinomaComplementary DNACoronaviridae InfectionsCoronavirus InfectionsCryo-electron MicroscopyCryoelectron MicroscopyDataDevelopmentDipeptidyl AminopeptidasesDipeptidyl PeptidasesDipeptidyl-Peptidase IVDipeptidylpeptide HydrolasesEcho Virus InfectionsEcho VirusesEchovirusEchovirus InfectionsEctopic ExpressionElectron CryomicroscopyEncephalitisFDA approvedFc ReceptorFcRnFcRn neonatal transfer proteinFoundationsFutureGastroenteritisGene Knock-Out ModelGenerationsGenesGoalsHost FactorHost Factor ProteinHumanImmune responseImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIn VitroIndividualInfectionInfection preventionInnate Immune ResponseIntegration Host FactorsInterferometryIntestinalIntestinesKnock-inKnock-outKnockoutKnowledgeMERS corona virusMERS coronavirusMERS virusMERS-CoVMapsMediatingMeningitisMiceMice MammalsMiddle East Respiratory Syndrome Corona VirusMiddle East Respiratory Syndrome CoronavirusMiddle East Respiratory Syndrome VirusMiddle East Respiratory Syndrome-CoVMiddle East Respiratory VirusMiddle East Respiratory coronavirusMiddle Eastern Respiratory Syndrome Corona virusMiddle Eastern Respiratory Syndrome CoronavirusMiddle Eastern Respiratory Syndrome VirusMiddle Eastern Respiratory Syndrome-CoVModelingModern ManMolecularMolecular InteractionMurineMusNorovirusNorwalk-like VirusesPathogenesisPeptide DomainPhysiologicPhysiologicalPreclinical TestingPrevent infectionProtein DomainsProteinsRNA VirusesReceptor ProteinResearchRoleRotavirusSeroprevalencesSpecies SpecificityStomachStrains Cell LinesStructureSystemTechniquesTechnologyTertiary Protein StructureTestingTransgenic OrganismsTropismVaccinesViralViral DiseasesViral GastroenteritisViral ReceptorVirionVirusVirus DiseasesVirus ParticleVirus Receptorsactivating CRISPR technologyadaptive immune responseaminoacidanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantibody receptorbiophysical analysisbiophysical studiesbowelcDNAcell culturecell culturescell immortalizationclustered regularly interspaced short palindromic repeats screencombatcryo-EMcryoEMcryogenic electron microscopycultured cell linedevelopmentalevaluate vaccinesfightingflugastricgenetic analysisgenome scalegenome-widegenomewidehigh definitionhigh-resolutionhost responsehuman modelimmune system responseimmunoresponseimmunosuppressed patientin vivoinhibitorinnate immune pathwaysinsightknockinmodel of animalmodel of humanmortalitymouse modelmurine modelneonatal Fc receptornoveloverexpressoverexpressionpediatricpermissivenesspharmacologicpre-clinical testingreceptorreceptor bindingreceptor boundreceptor expressionreceptor functionreverse geneticsscreeningscreeningssocial roletooltransgenicvaccine evaluationvaccine screeningvaccine testingviral infectionviral infectious disease treatmentvirus host interactionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY/ABSTRACT
Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis, and can cause disseminated
infection in immunocompromised hosts. Seroprevalence studies indicate almost universal HAstV infection during
childhood. Despite their clinical importance, HAstVs are highly understudied. Little is known about the host…
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