grant
Structural and chemical biology
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAcyl CoAAcyl Coenzyme AAcylationAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnabolismAnemiaAreaAssayAtaxiaAtaxyAttentionAutoregulationBindingBioassayBiochemicalBiologicalBiological AssayBiologyBrachydanio rerioCOVID-19CV-19Cancer TreatmentCancersCarbonCardiovascular DiseasesCatalysisCell BodyCell Communication and SignalingCell FunctionCell Membrane LipidsCell PhysiologyCell ProcessCell SignalingCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChemicalsCofactor Protein SCollaborationsCoordination ImpairmentCoronavirus Infectious Disease 2019Cryo-electron MicroscopyCryoelectron MicroscopyCuesCysteineCytoplasmic MembraneDanio rerioDegenerative Neurologic DisordersDiseaseDisorderDrug TherapyDyssynergiaElectron CryomicroscopyElementsEnzyme GeneEnzymesEquilibriumEukaryotaEukaryoteFamilyFamily memberFatty Acyl CoAFe elementFe overloadFerroprotoporphyrinGeneticGoalsHalf-CystineHemeHexadecanoyl CoAHomeostasisHumanHuntington ChoreaHuntington DiseaseHuntington'sHuntington's DiseaseHuntingtons DiseaseHydrophobicityIn VitroIntegral Membrane ProteinIntracellular Communication and SignalingIntrinsic Membrane ProteinIronIron OverloadKnowledgeL pneumophilaL-CysteineL. pneumophilaLeadLegionellaLegionella pneumoniaLegionella pneumophilaLegionella pneumophila InfectionsLegionnaires' DiseaseLegionnaires' pneumoniaLinkLipidsLiteratureLong-Chain Acyl CoAMacrophageMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMembraneMembrane LipidsMembrane Protein GeneMembrane ProteinsMembrane Structure and FunctionMembrane-Associated ProteinsMetabolicMetal Ion BindingMetalsMethodsMitochondriaModern ManMolecularMolecular InteractionMutateMφNamesNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOrganismPalmitoyl CoAPalmitoyl Coenzyme APalmityl CoAParalysis AgitansParkinsonParkinson DiseasePb elementPeptide FragmentsPharmacological TreatmentPharmacotherapyPhosphorylationPhysiological HomeostasisPlasma MembranePlayPneumoniaPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProliferatingPropertyProtein FamilyProtein ModificationProtein PhosphorylationProtein SProteinsProtohemeReactionRecombinantsResolutionRoleS elementS-hexadecanoate Coenzyme ASignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSingle Crystal DiffractionStarvationStructureSubcellular ProcessSulfurSurfaceSurface ProteinsTimeTouchTouch sensationTransition ElementsTranslatingTransmembrane ProteinTransmembrane Protein GeneUniversitiesVacuoleVirusVitamin K-Dependent Protein SX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray CrystallographyZebra DanioZebra FishZebrafishanti-cancer therapybacteria pathogenbacterial pathogenbalancebalance functionbiologicbiological signal transductionbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbiosynthesiscancer therapycancer-directed therapycardiovascular disordercell biologycofactorcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19cryo-EMcryoEMcryogenic electron microscopydeacylationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdrug discoverydrug interventiondrug treatmentenzyme mechanismexperimentexperimental researchexperimental studyexperimentsferrohemeheavy metal Pbheavy metal leadheme biosynthesishuman diseasein vitro Assayinhibitorinsightinterestliving systemmalignancymembermembrane structuremitochondrialmutantnamenamednamingneoplasm/cancerneurodegenerative illnessneuropsychiatric diseaseneuropsychiatric disordernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxygen transportpalmitoylationpathogenpathogenic bacteriapharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplasmalemmapreferenceprimary degenerative dementiaproteoliposomesreconstitutereconstitutionresolutionsresponsesenile dementia of the Alzheimer typesmall moleculesocial rolesynthetic peptidetactile sensationtooltransition metal
Description preview
1) Structure and function of eukaryotic integral membrane enzymes that catalyze protein lipidation -
A. Structural and chemical biology of zDHHC proteinacyltransferases - Of the different forms of protein lipidation, protein S-acylation, commonly known as protein palmitoylation, is the most prevalent. Thousands of cellular proteins are modified…
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