grant
Stromal Effects in Head and Neck Squamous Cell Carcinoma
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 5 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D3D cell culture3D cultureAnimal ModelAnimal Models and Related StudiesAreaAutoregulationBody TissuesCancer TreatmentCancersCarcinomaCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell Growth in NumberCell InteractionCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCharacteristicsChemoattractantsChemotactic FactorsChemotaxinsClinicalCo-cultureCocultivationCocultureCoculture TechniquesComplexComputer AnalysisDataDevelopmentDimensionsDiphtheriaDiseaseDisorderDrug ScreeningEpidermoid CarcinomaEpithelial cancerEpitheliumErinaceidaeFaceFibroblastsFoundationsGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGeneticGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGoalsGrowthHNSCCHarvestHead and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaHedgehogsHeterogeneityHigh Throughput AssayHistopathologyHomeostasisHumanImageIn VitroIntracellular Communication and SignalingIntratumoral heterogeneityInvadedKeratinocyte tumorLineage TracingLinkMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Head and Neck NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMolecularMorphogenesisMurineMusNatureNeoplasm MetastasisNormal TissueNormal tissue morphologyOralOrganOrganoidsPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPlanocellular CarcinomaPlayPopulationPrimary NeoplasmPrimary TumorProcessProgenitor CellsPropertyRecruitment ActivityResearch SpecimenRoleSCCHNSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSoilSpecimenSquamous CarcinomaSquamous Cell EpitheliomaSquamous cell carcinomaSubcellular ProcessSystemTechniquesTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranslatingTransplantationTumor Cell InvasionTumor InvasionTumor TissueTumorigenicityValidationVascularizationactive recruitmentanalyze gene expressionanti-cancer therapybiological signal transductionbiomarker identificationcancer cellcancer initiationcancer metastasiscancer microenvironmentcancer progressioncancer therapycancer typecancer-directed therapycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcomplement chemotactic factorcomputational analysescomputational analysiscomputer analysescraniofacialcraniofaciesdevelopmentalepithelial carcinomafacesfacialgene expression analysisgene expression assayglioma associated oncogene 1glioma associated oncogene family zinc finger 1global gene expressionglobal transcription profilehead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerheterogeneity in tumorshigh throughput screeningidentification of biomarkersidentification of new biomarkersimagingin vivointra-tumoral heterogeneityintratumor heterogeneityloss of functionmalignancymalignant head and neck tumormarker identificationmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmodel of animalmorphogenetic processneoplasm progressionneoplasm/cancerneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyorgan chiporgan on a chiporgan on chippathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpostnatalprogenitorprogenitor cell nicheprogenitor cell poolprogenitor cell populationprogenitor nicheprogenitor poolprogenitor populationpublic health relevancescRNA sequencingscRNA-seqself assemblysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial molecular analysisspatial molecular imagingspatial molecular mappingspatial molecular profilingspheroidsstemstem and progenitor cell nichestem and progenitor cell populationstem cell nichestem cell poolstem cell populationstem cellsstromal progenitorstromal stem cellthree dimensionalthree dimensional cell culturetooltranscriptional profilingtranscriptometranscriptomicstranslational studytransplanttumortumor cell metastasistumor heterogeneitytumor initiationtumor microenvironmenttumor progressionvalidations
Description preview
Squamous cell carcinoma of the head and neck (HNSCC) is a complex disorder that contains multiple cell
populations, making it is difficult to study the nature and cellular function and delineate relationship among
subpopulations. The analysis of global gene expressions in single cell level has evolved at an astounding pace
in the past few years,…
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