grant
Striatal Projection Neuron Changes in Dopamine Depletion and Parkinsons Disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ALDHAnatomic SitesAnatomic structuresAnatomyAutonomic DysfunctionAxonBasal GangliaBasal NucleiBradykinesiaCell CompartmentationCell CompartmentationsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCompensationCorpus StriatumCorpus striatum structureD1 receptorD2 receptorDA NeuronDRD2 ReceptorDeep Brain StimulationDegenerative Neurologic DisordersDevelopmentDisturbance in cognitionDopamineDopamine D1 ReceptorDopamine D2 ReceptorDopamine neuronDorsalDrug TherapyExhibitsGeneticGlobus PallidusGoalsHistologicHistologicallyHydroxytyramineImpaired cognitionLabelLinkLocomotionLocomotor ActivityMapsMental DepressionMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModificationMolecularMolecular FingerprintingMolecular ProfilingMotorMotor ActivityMovementMurineMusNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOutputParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatientsPharmacological TreatmentPharmacotherapyPlayPopulationPrimary ParkinsonismRegulationResearchRest TremorRoleShapesStriate BodyStriatumSubstantia NigraSubstantia nigra structureTestingVentral Tegmental AreaWorkaldehyde dehydrogenasesaphakia micebody movementcell typecognitive dysfunctioncognitive lossdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondevelopmentaldopaminergic neurondrug interventiondrug treatmentfallsinsightlocomotor controlmolecular profilemolecular signaturemotor behaviormotor controlmotor symptommouse modelmurine modelneural controlneural regulationneurodegenerative illnessneuromodulationneuromodulatoryneuronalneuroregulationnoveloptogeneticspallidumpars compactapathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsposture instabilitypreservationsocial rolestriatalstriosomeventral tegmentum
Description preview
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by hallmark motor symptoms—resting tremor, bradykinesia, rigidity, and postural instability—as well as a broad spectrum of non-motor manifestations including depression, cognitive decline, and autonomic dysfunction. The motor features of PD primarily result from the…
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