grant
Stressor controllability: Prefrontal circuits that produce resilience and dominance
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 1 Apr 1993Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Adverse ExperienceAdverse eventAppetiteBehavior ControlBehavioralBehavioral ManipulationBrain StemBrainstemCausalityClinicalCommunicationCorpus StriatumCorpus striatum structureDataDesire for foodDominance HierarchyElementsEtiologyEventExposure toFemaleFutureGoalsGrantHabitsHumanImmunizationIndividualLabelLeadLearningLifeLong-Term EffectsMedialMediatingMental DepressionModern ManNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganismOutcomePTSDPathway interactionsPatternPb elementPlayPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrefrontal CortexProcessResearchResistanceRodentRodentiaRodents MammalsRoleSocial DominanceStressStriate BodyStriatumStructureSystemThalamic structureThalamusWorkbehavior outcomebehavioral controlbehavioral outcomecausationdepressiondisease causationdorsal raphe nucleusexperiencegeneralized anxietyheavy metal Pbheavy metal leadinformation processingliving systemmaleneuralneural mechanismneurochemicalneurochemistryneuromechanismneuronalpathwaypost-trauma stress disorderposttrauma stress disorderpreventpreventingprotective effectresilienceresilientresilient to stressresistantresponsesexsocialsocial rolestress bufferingstress managementstress resiliencestress resiliencystressorstriatalthalamictraumatic eventtraumatic neurosis♀♂
Description preview
Project Summary/Abstract
The degree of behavioral control that an organism (rodent to human) can exert over an adverse event is
arguably the most potent variable yet discovered that modulates the impact of that event. When the organism
does have an element of control, the behavioral and neurochemical sequelae of the adverse event are blunted
or…
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