grant
Stress Response Pathways Regulating Protein Homeostasis
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AgingAreaBiophysicsCell BodyCell SurvivalCell ViabilityCellsCellular StressCellular Stress ResponseCellular biologyDiseaseDisorderLifeMessenger RNAMolecularPathway interactionsProcessProtein BiosynthesisProteinsQuality ControlRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesStressTailTranslationsbiological adaptation to stressbiophysical analysisbiophysical foundationbiophysical principlesbiophysical sciencesbiophysical studiescell biologycell stressinsightmRNApathwayprotein homeostasisprotein synthesisproteostasisreaction; crisisresponsestress responsestress; reactiontooltranslation
Description preview
Project Abstract
Cellular stress response pathways are fundamental survival strategies that regulate protein homeostasis and
are misregulated in myriad diseases and aging. The mechanisms by which stress response pathways regulate
protein homeostasis, how well these mechanisms can perform, and why they fail in disease are major open
questions. We…
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