grant
Stem Cell Dysfunction in Aged Skeletal Muscle
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldADP RiboseADP Ribose TransferasesADP ribosylationADP-RibosyltransferaseADPRTsAML1-Regulated Transmembrane Protein 1AP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinART TransferasesART1ARTasesActivator Protein-1AddressAdenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-riboseAdenosine 5'-DiphosphoriboseAdenosine Diphosphate RiboseAdenosine DiphosphoriboseAdultAdult HumanAffectAgeAgingAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBiology of AgingBody TissuesCUT&RUNCell Communication and SignalingCell CycleCell Division CycleCell SignalingCell surfaceCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClinicConsumptionDataDeteriorationDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDysfunctionElderlyEnhancer-Binding Protein AP1Enzyme GeneEnzymesEventExerciseFBJ osteosarcoma oncogeneFOS geneFunctional disorderG0S7Gene ActivationGene TargetingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticHealthHourImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInjuryIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLaboratoriesLacZLacZ GenesLeftMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedicalMiceMice MammalsMolecularMurineMusMuscleMuscle AtrophyMuscle TissueMuscular AtrophyMutateNadideNatural regenerationNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNull MouseOrganOrganoidsPHEMXPHEMX genePan-Hematopoietic Expression GenePathway interactionsPatternPhysiopathologyPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProgenitor CellsProtein ModificationProteinsProtocolProtocols documentationProtooncogene FOSRegenerationReporterSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSpeedSupplementationSystemTSPAN32TSSC6TestingTetraspanin 32TherapeuticTissuesTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription factor genesTraumaTumor-Suppressing STF cDNA 6Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 6Voluntary MuscleWorkadult progenitoradult stem celladult youthadulthoodadvanced ageagedaged groupaged groupsaged individualaged individualsaged muscleaged peopleaged personaged personsaged populationaged populationsagesaging of muscleaging populationaging processbiological signal transductionc fosc-fos Genec-fos Proto-Oncogenescofactorconditional knock-outconditional knockoutdecline in functiondecline in functional statusdiet supplementdietary supplementsdrivingextracellularfunctional declinefunctional status declinegain of functiongeriatrichealingimprovedin vivoinjuriesloss of functionmouse modelmurine modelmuscle agingmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle fiber repairmuscle formmuscle lossmuscle massmuscle progenitormuscle progenitor cellmuscle repairmuscle stem cellmuscle strengthmuscle systemmuscle tissue repairmuscle wastingmuscularmuscular repairmuscular systemnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnicotinamide ribonucleosidenicotinamide ribosenicotinamide ribosidenicotinamide-beta-ribosidenovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachnutritional supplementoverexpressoverexpressionpathophysiologypathwaypharmacologicpopulation agingprogenitor cell functionprogenitor cell poolprogenitor cell populationprogenitor functionprogenitor poolprogenitor populationprogramsregenerateregeneration potentialregenerativeregenerative potentialregenerative tissuerepairrepairedresponsesenior citizenskeletal preservationsomatic progenitorsomatic stem cellstem and progenitor cell functionstem and progenitor cell populationstem and progenitor functionstem cell functionstem cell poolstem cell populationstem cellstissue repairtranscription factorv-FOS FBJ Murine Osteosarcoma Viral Oncogene Homologvirtualyoung adultyoung adult ageyoung adulthood
Description preview
Abstract
One of the greatest mysteries in ageing biology is to understand why many tissues and organs in our body,
including skeletal muscle, decline in function as we get older? Recent studies suggest that the inability of
muscle stem cells (MuSCs) to turn on the repair program after trauma is a major factor leading to the loss of
muscle mass and…
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