grant
Stem cell-derived exosomes to ameliorate chemobrain
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 13 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202614-Hydroxydaunomycin21+ years oldAdjuvant ChemotherapyAdjuvant Drug TherapyAdriablastinAdriablastineAdriacinAdriamycin PFSAdriamycin RDSAdriamycineAdriblastinAdriblastinaAdriblastineAdrimedacAdultAdult HumanAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimalsAnzataxArchitectureAsotaxBehavioralBrainBrain Nervous SystemBreast CancerBristaxolCBDCACDDPCTXCYCLO-cellCancer ModelCancer SurvivorCancer TreatmentCancerModelCancersCarboplatinCarboplatinoCaringCarloxanCell Communication and SignalingCell SignalingChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureChronicCiclofosfamidaCiclofosfamideCicloxalCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClafenClapheneClinicalClinical DataClinical ResearchClinical StudyCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCombination Chemotherapy RegimenCornu AmmonisCranial IrradiationCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCysplatynaCytophosphanCytophosphaneCytoxanDOXO-CELLDataDegenerative Neurologic DisordersDichlorodiammineplatinumDiseaseDisorderDisturbance in cognitionDoxolemDoxorubicinDoxorubicinaDoxorubinDrug KineticsDysfunctionEffectivenessEmotionalEncephalonEndoxanEndoxanaEnduxanEngineering / ArchitectureFarmiblastinaFosfaseronFoundationsFunctional disorderGene TargetingGeneralized GrowthGenesGenoxalGenuxalGrowthHeterograftHeterologous TransplantationHippocampusHumanHydroxyl DaunorubicinHydroxyldaunorubicinIatrogenic CancerImpaired cognitionImpairmentIn VitroIncidenceInflammationInflammatoryInjectionsIntracellular Communication and SignalingIntravenousLedoxinaLiposomal AdriamycinMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMediatingMiceMice MammalsMicroRNAsMitoxanModelingModern ManMolecularMurineMusNeosarNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural Stem CellNeural degenerative DisordersNeurobiologyNeurocognitiveNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOvary CancerPaclitaxelPaclitaxel (Taxol)PathologicPatientsPerformancePeyrone's ChloridePeyrone's SaltPharmacokineticsPhysiopathologyPlatinum DiamminodichloridePlayPraxelPreclinical dataProcytoxProgenitor CellsPublishingQOLQuality of lifeQuimioterapiaRadiation therapyRadiotherapeuticsRadiotherapyRegimenResearch DesignRoleRubexSafetySendoxanSeriesSignal TransductionSignal Transduction SystemsSignalingSpinal ColumnSpineStructureStudy TypeSurvivorsSyklofosfamidSynapsesSynapticTaxolTaxol ATaxol KonzentratTestingTherapeuticTherapy Related Malignant NeoplasmTherapy Related Malignant TumorTherapy-Associated CancersTherapy-Related CancerTissue GrowthToxic effectToxicitiesTransgenic MiceTranslatingTransplantationTreatment-Associated CancerTreatment-Related CancerValidationVeinsVertebral columnXenograftXenograft procedureXenotransplantationZytoxanadriamycinadulthoodamygdaloid nuclear complexanti-cancer therapybackbonebiological signal transductionbrain irradiationbrain radiationcancer chemotherapycancer therapycancer-directed therapycandidate identificationcare giver stresscaregiver distresscaregiver stresschemo-/radio-therapychemo-induced cognitive declinechemo-radiotherapychemobrainchemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapychemotherapychemotherapy-associated cognitive impairmentchemotherapy-induced cognitive declinechemotherapy-induced cognitive dysfunctionchemotherapy-induced cognitive impairmentchemotherapy-related cognitive declinechemotherapy-related cognitive dysfunctionchemotherapy-related cognitive impairmentcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcognitive defectscognitive dysfunctioncognitive functioncognitive impairment due to chemotherapycognitive losscognitive taskcopingcranial radiationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdensityeffectiveness testingextracellular vesiclesfrontal cortexfrontal lobehippocampalimprovedin vivointervention designirradiationmalignancymalignant breast tumormedial temporal areamedial temporal lobemesial temporal areamesial temporal lobemiRNAmouse modelmurine modelneoplasm/cancernerve cell deathnerve cell lossnerve stem cellneural inflammationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurobiologicalneurodegenerative illnessneurogenesisneurogenic progenitorsneurogenic stem cellneuroinflammationneuroinflammatoryneuron cell deathneuron cell lossneuron deathneuron lossneuron progenitorsneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneuroprotectionneuroprotectivenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyovarian cancerpathophysiologypost-chemotherapy cognitive impairmentpre-clinical studypreclinical findingspreclinical informationpreclinical studypreventpreventingprogenitor and neural stem cellsprogenitor derived exosomesprogenitor exosomesprotein expressionradiation treatmentradio-chemo-therapyradio-chemotherapyradiochemotherapyregenerative approachregenerative strategyregenerative techniqueresponsesafety testingside effectsocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsstem cell derived exosomesstem cell exosomesstem cellsstress among caregiverstress in caregiverstress on caregiverstudy designsynapsetherapeutic outcometherapy designtherapy outcometransplanttreatment designtreatment with radiationvalidationsxeno-transplantxeno-transplantation
Description preview
ABSTRACT
Numerous clinical and preclinical studies have established the debilitating neurocognitive side
effects of various chemotherapy regimens for the treatment of cancer, often referred as
chemobrain. With substantial increases in the number of cancer survivors, over 16.9 million in the
U.S. alone, cognitive function following cancer treatment…
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