grant
Statistical Methods for Data Integration and Applications to Genome-wide Association Studies
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 23 Sept 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AccountingAdult-Onset Diabetes MellitusAlgorithmsBiological MarkersBreastBreast CancerCOVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 deathCOVID-19 fatalityCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 mortalityCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 mortalityCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCancer PatientCancersCharacteristicsCohort StudiesComplexComplex Genetic TraitComputational algorithmComputer Software ToolsComputer softwareComputerized Medical RecordCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDataData AnalysesData AnalysisData SetDevelopmentDimensionsDiseaseDisease OutcomeDisorderDisparateElectronic Medical RecordEnvironmental FactorEnvironmental Risk FactorEstimation TechniquesGWA studyGWASGene x Environment InteractionGeneticGenetic MarkersGenetic ModelsGenetic studyGenome ScanGxE interactionHigh-dimensional ModelingIndividualKetosis-Resistant Diabetes MellitusLinear ModelsLungLung Respiratory SystemMajor Depressive DisorderMalignant Breast NeoplasmMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMapsMaturity-Onset Diabetes MellitusMediatingMediationMelanomaMental disordersMental health disordersMethodsModelingModernizationModificationNIDDMNegotiatingNegotiationNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOutcomeParameter EstimationPhenotypePopulationPopulation HeterogeneityPredicting RiskPrivacyPsychiatric DiseasePsychiatric DisorderPublishingPulmonary CancerPulmonary malignant NeoplasmRiskRisk FactorsSARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 fatalitySARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 mortalitySARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySample SizeSeriesSlow-Onset Diabetes MellitusSoftwareSoftware ToolsSourceStable Diabetes MellitusStatistical MethodsStructureT2 DMT2DT2DMTestingTumor SubtypeType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadult onset diabetesatherosclerotic coronary diseasebio-markersbiobankbiologic markerbiomarkerbiorepositorycardiometaboliccardiometabolismcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantclinical depressioncohort research studycohort surveycomputer algorithmcomputer based predictionconditioningcoronary arterial diseasecoronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 deathcoronavirus disease 2019 fatalitycoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 mortalitycoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease-19 mortalitydata integrationdata interpretationdeath due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2death riskdevelopmentaldisease diagnosisdisease modeldisease riskdisorder modeldisorder riskdiverse populationsenvironment effect on geneenvironmental riskepidemiology research studyepidemiology studyepidemiology surveyfatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2forecasting riskgene biomarkergene environment interactiongene expression biomarkergene markergene signature biomarkergenetic associationgenetic biomarkergenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenome-wide scangenomewidegenomewide association scangenomewide association studygenomewide scanheterogeneous populationhigh dimensionalityinsightinterestketosis resistant diabeteslarge scale datalarge scale data setslarge scale datasetslife-style factorlifestyle factorslow-frequency mutationlung cancermajor depressionmajor depression disordermalignancymalignant breast tumormaturity onset diabetesmental illnessmethod developmentmodel buildingmortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2mortality riskmultidimensional modelingneoplasm/cancernon-geneticnongeneticnovelphenotypic datapolygenetic risk scorespolygenic risk scorepopulation diversitypower analysispractical implementationpragmatic implementationpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive modelingpredictive riskpredicts riskpsychiatric illnesspsychological disorderrare allelerare mutationrare variantreference assemblyreference genomerisk predictionrisk prediction algorithmrisk prediction modelrisk predictionssevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalitysocio-demographicssociodemographicssoftware toolkitstatistic methodsstatisticstheoriestraittumortype 2 DMtype II DMtype two diabetesuser friendly computer softwareuser friendly softwareuser-friendlywhole genome association analysiswhole genome association studywhole-genome scan
Description preview
Abstract
Large-scale epidemiologic studies, including biobanks and genome-wide association
studies (GWAS), are now rapidly leading to the identification of novel risk factors for
complex diseases. There is increasing opportunity to develop comprehensive models for
disease risk incorporating genetic markers, other biomarkers, life-style factors and…
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