grant
Statistical Methods for Accurate Estimation and Prediction in Alzheimer's Disease
Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 15 May 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD modelActive Follow-upAddressAge of OnsetAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease modelAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaBiological MarkersBloodBlood Reticuloendothelial SystemBrain Metabolic DisordersCOVID-19CV-19Cessation of lifeClinicalClinical TrialsClinical Trials DesignCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCoronavirus Infectious Disease 2019Data SetDeathDementiaDevelopmentDisease ProgressionDisturbance in cognitionDrug TherapyEligibilityEligibility DeterminationEventImpaired cognitionImpairmentIndividualLeftLengthLong-term cohort studyLongitudinal cohort studyMaternal AgeMeasuresMetabolic Brain DiseasesMetabolic Brain SyndromesMetabolic EncephalopathiesMethodsModelingNeurologicNeurologicalObservation researchObservation studyObservational StudyObservational researchOutcomeParticipantPatientsPharmacological TreatmentPharmacotherapyPredispositionPreventionPrimary Senile Degenerative DementiaProbabilityProtocol ScreeningPublic HealthPublishingRegression AnalysesRegression AnalysisRegression DiagnosticsResearch ResourcesResourcesRiskRisk AssessmentSamplingSampling BiasesStatistical MethodsStatistical RegressionSusceptibilityTimeUncertaintyactive followupacute COVID-19acute SARS-CoV-2 infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectionage at pregnancyaged brainaging brainalzheimer modelamyloid imagingauthoritybio-markersbiologic markerbiomarkerclinical predictorsclinical relevanceclinically relevantcognitive dysfunctioncognitive losscohortcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19designdesigningdevelopmentaldoubtdrug developmentdrug interventiondrug treatmenteffective therapyeffective treatmentexpectationflexibilityflexiblefollow upfollow-upfollowed upfollowupimprovedinterestmachine learning based methodmachine learning methodmachine learning methodologiesmild cognitive disordermild cognitive impairmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprediction algorithmprimary degenerative dementiaprognosticsenile dementia of the Alzheimer typesimulationstatistic methodstime usetrial design
Description preview
Project Summary
Longitudinal cohort studies are a rich resource for estimation and modeling of Alzheimer's disease (AD)
progression. Datasets extracted from these studies often feature complex truncation (selection) and
censoring. Estimates based on these datasets are used for (1) clinical trial design; (2) improved understanding
of AD…
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