grant
Stanford O'Brien Urology Research Center
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Sept 2021Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAffectAtlasesAutomobile DrivingB-Cell Attracting Chemokine 1B-Lymphocyte ChemoattractantBCA1BLC geneBLC proteinBenignBenign Prostatic HyperplasiaBenign Prostatic HypertrophyBioinformaticsBiologyBody TissuesCXCL13CXCL13 geneCell BodyCell Communication and SignalingCell FunctionCell NucleusCell PhysiologyCell ProcessCell SignalingCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessChemokine, CXC Motif, Ligand 13ClinicalCollaborationsCommunicationCommunitiesDataData AnalysesData AnalysisDevelopmentDimensionsDiseaseDisorderDysfunctionElementsEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEnsureEpithelial CellsEpitheliumEpithelium of Human Prostate GlandFibroblastsFibrosisFunctional disorderGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneral RadiologyGeneralized GrowthGoalsGrowthGrowth and DevelopmentGrowth and Development functionHeterogeneityHistologicHistologicallyHistologyHumanImageImmuneImmune responseImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInfiltrationInflammationInflammatoryInternationalIntracellular Communication and SignalingInvestigationInvestigatorsLeadMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingModern ManMolecularMultiplexed Ion Beam ImagingNIDDKNMR ImagingNMR TomographyNational Institute of Diabetes and Digestive and Kidney DiseasesNuclear Magnetic Resonance ImagingNucleusPathogenesisPathway interactionsPatientsPb elementPhysiopathologyPilot ProjectsPlayPopulationProliferatingProstateProstate DiseaseProstate GlandProstatic DiseasesProstatic EpitheliumProstatic GlandProstatic Portion of the Male UrethraProstatic UrethraRadiologyRadiology SpecialtyReportingResearchResearch PersonnelResearch ResourcesResearchersResource SharingResourcesRoleSCYB13SamplingScienceScientistServicesShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSmall Inducible Cytokine Subfamily B, Member 13Stromal CellsSubcellular ProcessSymptomsTechnologyTestingTherapeuticTimeTissue ExpansionTissue GrowthTissuesTrainingTranscript Expression AnalysesTranscript Expression AnalysisUrinary Tract DiseasesUrologic DiseasesUrologic DisorderUrological DiseasesUrological DisordersUrologyZeugmatographyanalyze gene expressionassociated symptombenign prostate hyperplasiabio-imagingbioimagingbiological signal transductioncell growthcell typeco-morbid symptomco-occuring symptomcomorbid symptomconcurrent symptomcooccuring symptomdata de-identificationdata deidentificationdata interpretationde-identified datadeidentified datadevelopmentaldrivingexperienceexpression subtypesgene expression analysisgene expression assaygenomic datagenomic datasetgraduate studentheavy metal Pbheavy metal leadhistologic imagehistological imagehost responsehuman diseaseimagingimmune microenvironmentimmune system responseimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedindexinginjury responselower urinary tract symptomsmanmenmolecular sub-typesmolecular subsetsmolecular subtypesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generationnext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approacholder menontogenypathophysiologypathwaypilot studypreventpreventingprogramsprostate disorderprostate enlargementprostatic enlargementresponseresponse to injurysenescencesenescentsocial rolesuccesssymptom associationsymptom comorbiditythree dimensionalthree-dimensional modelingtranscriptional profilingtranscriptomicstranslational investigatortranslational researchertranslational scientisttumortumor immune microenvironmenttumor-immune system interactionsundergradundergraduateundergraduate studenturinaryurinary tract disorderurologicurological
Description preview
ABSTRACT – OVERALL COMPONENT
Benign prostatic hyperplasia (BPH) is the most common cause of urinary symptoms in older men, yet we
understand little about its origins, drivers of growth, and how it causes lower urinary tract symptoms. Since
BPH-caused Lower Urinary Tracts Symptoms (LUTS) appears unique to man, we propose a highly integrated
project…
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