grant
SSLs immune manipulation in S aureus colonization, infection, and a potential therapy against pneumonia
Organization LOUISIANA STATE UNIV A&M COL BATON ROUGELocation BATON ROUGE, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Adhesion MoleculeAdhesionsAffectAntibiotic ResistanceAntigen-Antibody ComplexBacteriaBacterial ToxinsBiological Response ModifiersBiomodulatorsBlocking AntibodiesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SerumBody TissuesBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageCRISPRCRISPR/Cas systemCausalityCell AdhesionCell Adhesion Molecule GeneCell Adhesion MoleculesCell Migration InhibitionCell Migration Inhibition functionCell surfaceCellular AdhesionClinicalClustered Regularly Interspaced Short Palindromic RepeatsDataDeath RateDedicationsDiseaseDisorderEnvironmentEpithelial CellsEquilibriumEtiologyExposure toFamily memberGene ClusterGenesGoalsHL-60 CellsHL60 CellsHost DefenseHumanImmuneImmune Cell ActivationImmune ComplexImmune EvasionImmune MediatorsImmune Mediators/ModulatorsImmune RegulatorsImmune responseImmune systemImmunesImmunomodulationImmunomodulatorsIndividualInfectionInflammatoryIntegrinsIntegrins Extracellular MatrixIntensive CareInvadedKnock-outKnockoutKnowledgeLavageLifeLungLung LavageLung Respiratory SystemLung damageLung infectionsMRSAMSSAMarrow NeutrophilMediatingMethicillin Resistant S. AureusMiceMice MammalsModelingModern ManMorbidityMorbidity - disease rateMotilityMurineMusNasalNasal Passages NoseNasal cavityNasopharynxNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNosePneumoniaPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPrevalenceProtein FamilyProteinsPulmonary PathologyRecombinantsResistance to antibioticsResistant to antibioticsRespiratory System, Nose, Nasal PassagesRhinopharynxRoleS aureusS. aureusS. aureus infectionSerumSignaling MoleculeSourceStaph aureusStaph aureus infectionStaphylococcal InfectionsStaphylococcus aureusStaphylococcus aureus infectionStaphylococcus infectionSuperantigensSystemTestingTissuesUnited StatesVRSAVaccinesVancomycin resistant S. aureusVancomycin resistant Staph aureusVancomycin-resistant S. aureusVancomycin-resistant S.aureusVancomycin-resistant Staphylococcus aureusantibiotic drug resistanceantibiotic resistantbalancebalance functionbronchiolar alveolar lavagebronchopulmonary lavage therapycare resourcescausationcell adhesion proteinclinical riskdesigndesigningdisease causationhealth care resourceshigh riskhost responseimmune activationimmune evasiveimmune modulationimmune modulatorsimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunomodulatory moleculesimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimmunoresponseinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinsightlavage therapylung injurylung pathologymethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmethicillin sensitive S . aureusmethicillin sensitive Staphylococcus aureusmethicillin susceptible Staphylococcus aureusmethicillin-susceptible S. aureusmigrationmortalitymortality ratemortality ratiomouse modelmurine modelnasopharnygealneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopportunistic pathogenpathogenpneumonia modelpneumonia modelspneumonia therapypneumonia treatmentprotein functionpulmonary damagepulmonary infectionspulmonary injurypulmonary tissue damagepulmonary tissue injurysocial rolestaph infectionstranslational studytreat pneumoniaventilator-acquired pneumoniaventilator-associated pneumonia
Description preview
PROJECT SUMMARY / ABSTRACT
Staphylococcus aureus associated pneumonia accounts for an estimated 50,000 staphylococcal infections
annually in the United States. S. aureus is one of the leading etiologic agents of ventilator-associated pneumonia
in the intensive care environment. S. aureus pneumonia has a high rate of mortality due to the…
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