grant
SREBP1 as a Novel Mammalian Oxygen Sensor
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025ADD-1 proteinADD1 proteinAcuteAffectAnimal Disease ModelsAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBinding SitesBioinformaticsBiologyBody TissuesBuffersC elegansC. elegansC.elegansCAT scanCOPDCT X RayCT XrayCT imagingCT scanCaenorhabditis elegansCarbonCardiovascular DiseasesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell SignalingCellsChIP SequencingChIP-seqChIPseqChronicChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseChronic lung diseaseCircadian gene expressionClinicalCombining SiteCommunicationComputed TomographyConsumptionCor pulmonaleCyanotic congenital heart diseaseCyanotic heart diseaseDNA BindingDNA Binding InteractionDNA Molecular BiologyDNA boundDNA mappingDataDevelopment PlansDietDiseaseDisorderEicosapentaenoic AcidExposure toFTPFatty AcidsFission YeastFoundationsFree Fatty AcidsFundingGene TranscriptionGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGoalsHTH DNA Binding DomainHTH MotifsHeart failureHelix-Turn-Helix MotifsHepatic CellsHepatic Parenchymal CellHepatocyteHexadecanoatesHomeostasisHomologHomologous GeneHomologueHourHypoxiaHypoxia Inducible FactorHypoxicImpairmentIntermediary MetabolismIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsKO miceKnock-out MiceKnockout MiceKnowledgeLaboratoriesLeadershipLeucine ZippersLigand Binding ProteinLigand Binding Protein GeneLipidsLiverLiver CellsLower OrganismLung DiseasesMammaliaMammalian CellMammalsMeasuresMediatingMediatorMentorsMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsMitochondrial DiseasesMitochondrial DisordersMolecularMolecular BiologyMolecular InteractionMonitorMorbidityMorbidity - disease rateMurineMusNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNonesterified Fatty AcidsNuclearNull MouseO elementO2 elementOleatesOrganismOverlapping GenesOxygenOxygen DeficiencyPalmitatesPathologyPathway interactionsPatientsPatternPersonsPhysiciansPhysiological HomeostasisPolyunsaturated Fatty AcidsPromoter RegionsPromotor RegionsProtein BindingPulmonary DiseasesPulmonary DisorderPulmonary Heart DiseasePulmonary Heart DisorderPulmonary HypertensionRNA ExpressionRNA SeqRNA sequencingRNAseqRadiolabeledReactive SiteResearchResearch Career ProgramResearch TrainingResponse ElementsRoleS pombeS. pombeSRE-1 binding proteinSREBP-1SREBP-1cSaturated Fatty AcidsSchizosaccharomyces pombeScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSoy BeansSoybeansSterolsStressStructureSystems BiologyTechnical ExpertiseTechniquesTestingTherapeuticThesaurismosisTimnodonic AcidTissuesTomodensitometryTracerTrainingTraining ProgramsTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTriacylglycerolTriglyceridesUnited StatesUnsaturated Fatty AcidsUpdateWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyYeastsbiological adaptation to stressbiological signal transductionbound proteincardiac failurecardiopulmonary diseasecardiopulmonary disordercardiovascular disordercareercatscanchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic obstructive pulmonary disorderchronic pulmonary diseasecomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographydietsdisease of the lungdisorder of the lungdouble bondeicosapentanoic acidexperimentexperimental researchexperimental studyexperimentsfat metabolismformycin 5'-triphosphateformycin A 5'-triphosphateformycin triphosphatefunctional genomicsgene networkgenetic promoter elementgenetic promoter sequencehelix loop helixhelix turn helixhepatic body systemhepatic organ systemlipid metabolismliving systemlung disorderlung hypoxiametabolism disordermicroPET/CTmortalityneurological diseasenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoxidationpalm oilpalmoleinpathwaypi bondprogramspromoter sequencepublic health relevancepulmonary hypoxiaradiolabelingradiologically labeledreaction; crisisresponsesaturated dietary fatsaturated dietary lipidsaturated fatsaturated lipidsensorskillssocial rolesterol regulatory element binding protein-1csterol regulatory element-binding protein 1stress responsestress; reactiontechnical skillstranscription factortranscription factor ADD1transcriptome sequencingtranscriptomic sequencinguptake
Description preview
ABSTRACT
Millions of people in the United States have cardiopulmonary diseases marked by chronic hypoxia, a persistent
reduction in oxygen availability and delivery to cells and tissues. In patients with diseases such as severe chronic
obstructive pulmonary disease or advanced heart failure, chronic hypoxia is associated with increased morbidity…
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