grant
Spreading Depolarization and Progression of Developmental Epileptic Encephalopathy
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 26 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY202521+ years oldAcuteAddressAdolescentAdolescent YouthAdultAdult HumanAffectAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnesthesiaAnesthesia proceduresAnimalsApoplexyAreaBasic ResearchBasic ScienceBehaviorBehavioralBiologicalBiological MarkersBlood flowBody TissuesBrainBrain Nervous SystemBrain StemBrain TraumaBrain Vascular AccidentBrainstemCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicClassic MigraineClassical MigraineClinicalClinical ResearchClinical StudyClinical TreatmentCognitiveCornu AmmonisData SetDetectionDevelopmentDiseaseDisease ProgressionDisorderDistantDropsyDysfunctionEEGEdemaElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEpilepsyEpileptic SeizuresEpilepticsEventExhibitsFemaleFrequenciesFunctional disorderGenerationsGenesGeneticGenotypeGliaGlial CellsGoalsHeart VascularHippocampusHourHumanHydropsHyperthermiaInterventionKolliker's reticulumLaboratoriesLifeMetabolicMethodsMiceMice MammalsMigraine with AuraMigraine with Typical AuraModelingModern ManMonitorMotorMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeurologicNeurologic DeficitNeurologic DysfunctionsNeurologicalNeuronsNeurophysiology / ElectrophysiologyNon-neuronal cellNonneuronal cellOutcomePathologicPathologyPatternPhenotypePhysiologyPhysiopathologyPre-Clinical ModelPreclinical ModelsPredispositionPremature MortalityResearchResearch ResourcesResourcesRiskRoleSUDEPScalpScalp structureSeizure DisorderSeizuresSensorySliceStrokeStructureSusceptibilitySystemTechniquesTestingTissuesTraumatic Brain Injuryacquired epilepsyadulthoodamygdaloid nuclear complexawakebio-markersbiologicbiologic markerbiomarkerbrain attackbrain tissuecerebral vascular accidentcerebrovascular accidentcircadiancirculatory systemclinical interventionclinical therapyco-morbidco-morbiditycomorbiditydata sharingdevelopmentaldevelopmental epileptic encephalopathydravet syndromeelectrophysiologicalepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptogenichigh riskhippocampalinsightjuvenilejuvenile humanmalemigrationmortalitymouse modelmulti-modalitymultimodalitymurine modelnerve cementneurobehavioralneurological dysfunctionneuronalneuronal circuitneuronal circuitryneuropathologicneuropathologicalneuropathologynoveloptogeneticspathophysiologypatients with epilepsypre-clinicalpre-clinical studypreclinicalpreclinical studyrespiratorysevere myoclonic epilepsy of infancysocial rolestrokedstrokessudden unexpected death in epilepsytooltraumatic brain damagetrial regimentrial treatmentvigilance♀♂
Description preview
PROJECT SUMMARY
Spreading depolarization (SD) is a wave of massive, near-complete cellular depolarization that slowly
propagates across brain tissue. Recent decades of clinical studies have convincingly demonstrated that this
prolonged depolarization wave occurs under certain conditions in the human brain and can contribute to
deleterious acute…
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