grant
Spontaneous activity in the developing auditory system
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Dec 2007Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AccelerationAction PotentialsApoptoticAudiogramAudiometric TestAudiometryAuditoryAuditory CortexAuditory areaAuditory systemBiosensorBody TissuesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCellular TransformationCochleaCochlear ImplantsCochlear OrganCochlear ProsthesisCommunicationCompensationComplexCorti ganglionDNA mutationDT-RDTR geneDataDevelopmentDiphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) GeneDiphtheria Toxin Receptor GeneDiphtheria Toxin Sensitivity GeneDrugsERK 1ERK MAP KinasesERK1ERK1 KinaseEpitheliumEventExhibitsExposure toExtracellular Signal Regulated KinasesExtracellular Signal-Regulated Kinase 1Extracellular Signal-Regulated MAP KinasesFrequenciesFundingGene ExpressionGeneticGenetic ChangeGenetic defectGenetic mutationGrowth AgentsGrowth FactorGrowth SubstancesHB-EGFHBEGFHEGFLHearingHearing LossHearing TestsHeparin-Binding EGF-Like Growth Factor GeneHypoacusesHypoacusisImageImpairmentIn vivo analysisInduction of ApoptosisInferior ColliculusInner Phalangeal CellInner Supporting CellInternal EarIntracellular Communication and SignalingKinasesKnowledgeL-TriiodothyronineLabyrinthLengthLifeLigandsLinkLiothyronineMAP Kinase 3MAPK ERK KinasesMAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMediatingMedicationMiceMice MammalsMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneMolecularMorphogenesisMorphologyMurineMusMutationNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganP44ERK1PSTkinase p44mpkPathway interactionsPerformancePeripheralPharmaceutical PreparationsPhasePhosphotransferase GenePhosphotransferasesPlayPosterior Quadrigeminal BodyProcessProteins Growth FactorsReceptor ProteinReporterRoleSensorySeriesSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStereotypingStructureSubcellular ProcessSupporting CellSystemSystems DevelopmentT-3T3 Thyroid HormoneTestingTherapeutic T3Therapeutic TriiodothyronineThreonine/Tyrosine Protein KinaseThyroid Gland HormoneThyroid HormonesTimeTissuesTrainingTransphosphorylasesTraumaTriiodothyronineUpregulationVisualizationauditory testsbiological sensorbiological signal transductiondeafnessdevelopmentaldevelopmental diseasedevelopmental disorderdrug induced hearing impairmentdrug induced hearing lossdrug/agentdysfunctional hearingex vivo imagingexperienceextracellular signal related kinasefluorescence imagingfluorescent imaginggene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationhearing assessmenthearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthormonal signalshormone signalsimagingimaging in vivoimprovedin vivoin vivo evaluationin vivo imagingin vivo testinginner earmetaplastic cell transformationmorphogenetic processmouse modelmurine modelneural patterningneuronalototoxicototoxicityp44 MAPKpathwaypharmacologicreceptorrelease factorsocial rolesoundsound frequencyspatial and temporalspatial temporalspatiotemporalspiral ganglion
Description preview
Project Summary
Neurons in the developing auditory system exhibit spontaneous activity prior to the onset of sensory
experience. This activity is initiated within the cochlea when non-sensory inner supporting cells release ATP,
triggering a cascade of events that ultimately induces trains of action potentials in spiral ganglion neurons
(SGNs). Our…
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