grant
Spindle Assembly Checkpoint Silencing
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Aug 2018Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025ATP phosphohydrolaseATPaseAdenosine TriphosphataseBindingCancersCardiac developmentCell CycleCell Cycle CheckpointCell Division CycleCell divisionCellular biologyChromatinChromosome SegregationChromosomesComplexCouplingCryo-electron MicroscopyCryoelectron MicroscopyCyclin BDefectDevelopmentDiseaseDisorderEAP1ESP1-Associated Protein 1Electron CryomicroscopyEnsureEukaryotic CellEventFirst Gap PhaseG1 PhaseG1 periodGap Phase 1Gene ExpressionGene ProteinsGene TranscriptionGenetic TranscriptionIn VitroKinasesM PhaseMalignant NeoplasmsMalignant TumorMetabolic Protein DegradationMitosisMitosis CheckpointMitosis StageMitoticMitotic CheckpointMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular MachinesMolecular StereochemistryNucleosomesPTTGPTTG1PTTG1 genePhosphotransferase GenePhosphotransferasesPhotometryPituitary Tumor-Transforming Gene 1PolyubiquitinationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein Gene ProductsProtein ModificationProtein TurnoverProteinsRNA ExpressionRegulationRegulatory Protein DegradationResearchSecurinTUTR1TechniquesTimeTranscriptionTransphosphorylasesTumor-Transforming 1UbiquitilationUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitinationUbiquitinoylationanaphase-promoting complexcancer progressioncardiogenesiscdc13 Proteincell biologycell cycle check pointchromosome divisionconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopycyclosomedaughter celldevelopmentalheart developmentheart formationinhibitorinnovateinnovationinnovativemalignancymitosis check pointmitotic check pointneoplasm progressionneoplasm/cancerneoplastic progressionp56cdc13protein degradationreconstitutereconstitutionscaffoldscaffoldingtumor progressionubiquinationubiquitin conjugationubiquitin ligase
Description preview
PROJECT SUMMARY
Eukaryotic cell cycle is tightly controlled by an intricate sequence of events where both gene expression and
protein degradation are under intense regulation. When the cell cycle is dysregulated, uncontrolled division
ensues–a hallmark of cancer. Therefore, cell cycle checkpoints, such as the spindle assembly checkpoint
(SAC),…
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