grant
Sphingolipid Signaling in Mammals
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active OxygenAreaAutoimmune DiseasesBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBiologicalBone Marrow Stem CellBone Marrow progenitorCell BodyCell Communication and SignalingCell ComponentsCell SignalingCell StructureCell membraneCellsCellular StructuresCeramidesCoenzyme IIColitisComplexCytoplasmic MembraneDevelopmentEAEEnzyme GeneEnzymesExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2GenesGlucocerebrosidesGlucosyl CeramidesGlucosylceramidesGlycolysisHIF 1HIF-1 proteinHIF1HIF1 proteinHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHematologic Body SystemHematologic Organ SystemHematopoietic Body SystemHematopoietic SystemHereditary Metabolic DisorderHumanImpairmentInborn Errors of MetabolismInducer CellsInducer T-LymphocytesInnate ImmunityIntermediary MetabolismIntracellular Communication and SignalingIntracellular Second MessengerInvestigatorsLipidsMammaliaMammalsMechanistic Target of RapamycinMembraneMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModern ManMultienzyme ComplexesMurineMusNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNative ImmunityNatural ImmunityNeuronal Cholesterol LipidosisNicotinamide-Adenine Dinucleotide PhosphateNiemann-Pick DiseasesNon-Specific ImmunityNonspecific ImmunityOxidasesOxygen RadicalsPathway interactionsPlasma MembranePlayPro-OxidantsProcessProteinsRAFT1Reactive Oxygen SpeciesReportingResearchResearch PersonnelResearchersRoleSecond Messenger SystemsSecond MessengersShapesSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedSphingolipidsT-CellsT-LymphocyteTriphosphopyridine Nucleotideacquired drug resistanceacquired immunityadaptive immune responseautoimmune conditionautoimmune disorderautoimmune encephalomyelitisautoimmunity diseasebiologicbiological signal transductionbone marrow derived progenitorbone marrow derived stem cellsbone marrow stromal cellbone marrow stromal stem cellc mycc-myc Genescmycdevelopmentalenzyme complexhuman diseasehypoxia inducible factor 1inborn metabolism disorderlipoid histiocytosis (classical phosphatide)mTORmammalian target of rapamycinmembrane structuremouse modelmurine modelpathwayplasmalemmaserine C-palmitoyltransferaseserine palmitoyltransferasesignal transduction second messengerssocial rolesphingomyelin lipidosissphingomyelinase deficiencythymus derived lymphocytetumorv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog
Description preview
We have demonstrated critical roles of the de novo biosynthetic patway in specification and differentiation of various lineages of the bone marrow stem cells.Recently we reported on the role of SPTLC1 in T helper cells development and differentiation. T helper 17 (TH17) cells are implicated in autoimmune diseases, and several metabolic processes…
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